Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.63 |
| ▸ | CXCR2 | P25025 | 10/20 | 0.59 |
| ▸ | CXCR1 | P25024 | 7/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.56 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.56 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.56 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.55 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.55 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.55 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9566852 | 0.92 | P4HTM (0.55) | P4HTMCXCR2CXCR1PTPN1PTPN6 | |
| SCHEMBL9517015 | 0.89 | P4HTM (0.51) | P4HTMCXCR2CXCR1PTPN1PTPN6 | |
| SCHEMBL9566835 | 0.85 | P4HTM (0.63) | P4HTMKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL9566802 | 0.85 | NPC1 (0.67) | P4HTMCXCR2CXCR1PTPN1KMT2A | |
| SCHEMBL9566902 | 0.83 | CXCR2 (0.62) | P4HTMCXCR2CXCR1PTPN1PTPN6 | |
| SCHEMBL9566803 | 0.82 | P4HTM (0.66) | P4HTMCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9566776 | 0.82 | P4HTM (0.66) | P4HTMCXCR2CXCR1KMT2AALDH1A1 | |
| SCHEMBL9566786 | 0.81 | CXCR2 (0.57) | P4HTMCXCR2CXCR1ALDH1A1 | |
| SCHEMBL9566868 | 0.81 | CXCR2 (0.60) | P4HTMCXCR2CXCR1ALDH1A1 | |
| SCHEMBL9566887 | 0.81 | P4HTM (0.69) | P4HTMCYP1A2CYP3A4KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533130-A1 | 2-Hydroxymethylpyridines, the corresponding pyridine-N-oxides and derivatives thereof, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-03-24 | — | — | EP | disclosed |