Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 5/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GPR6 | P46095 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29358580 | 1.00 | EP300 (0.42) | EP300GSK3BDYRK1ANPC1TSHR | |
| SCHEMBL21394628 | 0.87 | ALDH1A1 (0.41) | EP300NPC1TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL29357585 | 0.87 | ALDH1A1 (0.41) | EP300NPC1TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL21394938 | 0.84 | TMPRSS4 (0.47) | — | |
| SCHEMBL21394690 | 0.84 | NPC1 (0.47) | GSK3BDYRK1ANPC1TSHRRAB9A | |
| SCHEMBL29358408 | 0.84 | NPC1 (0.47) | GSK3BDYRK1ANPC1TSHRRAB9A | |
| SCHEMBL21394693 | 0.84 | SIRT2 (0.37) | — | |
| SCHEMBL29355390 | 0.84 | ABCC8 (0.38) | NPC1TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL21394482 | 0.84 | ABCC8 (0.38) | NPC1TSHRRAB9ASMN1; SMN2 | |
| SCHEMBL21395002 | 0.82 | TMPRSS4 (0.41) | NPC1TSHRRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118084800-A | Compounds and uses thereof | 詹森药业有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-118084801-A | Compounds and uses thereof | 詹森药业有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-112312913-B | Compounds and uses thereof | 詹森药业有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-114174273-A | Compounds and uses thereof | 优曼尼蒂治疗公司 | 2022-03-11 | — | — | CN | disclosed |
| CN-112312913-A | Compounds and uses thereof | 优曼尼蒂治疗公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |