SCHEMBL21394886

SCHEMBL21394886

CC(C)(C)OC(=O)Nc1ncc(C(O)c2ccc(Cl)cc2)s1

nearest known ligand 0.53

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
P2RY2 P41231 1/20 0.53
FFAR2 O15552 18/20 0.50
CCNE1 P24864 1/20 0.44
CDK2 P24941 1/20 0.44
CDK5 Q00535 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29358752 0.86 S1PR3 (0.46) P2RY2FFAR2CCNE1CDK2CDK5
SCHEMBL21394890 0.86 S1PR3 (0.46) P2RY2FFAR2CCNE1CDK2CDK5
SCHEMBL21395232 0.86 P2RY2 (0.43) P2RY2FFAR2CCNE1CDK2CDK5
SCHEMBL21394896 0.85 P2RY2 (0.42) P2RY2FFAR2CCNE1CDK2CDK5
SCHEMBL34467551 0.85 P2RY2 (0.42) P2RY2FFAR2CCNE1CDK2CDK5
SCHEMBL21395055 0.83 PSEN1 (0.42) P2RY2FFAR2CCNE1CDK2CDK5
SCHEMBL29356948 0.81 CCNE1 (0.47) P2RY2CCNE1CDK2CDK5
SCHEMBL21394900 0.81 CCNE1 (0.47) P2RY2CCNE1CDK2CDK5
SCHEMBL34467357 0.81 STAT3 (0.41) P2RY2FFAR2CCNE1CDK2CDK5
SCHEMBL21395247 0.81 PSEN1 (0.48) P2RY2CCNE1CDK2CDK5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260138977-A1 MODULATORS OF BETA CATENIN AND USES THEREOF DEWPOINT THERAPEUTICS INC (US) 2026-05-21 US disclosed
US-12612396-B1 Modulators of beta catenin and uses thereof DEWPOINT THERAPEUTICS, INC. (US) 2026-04-28 US disclosed
US-20230078764-A1 COMPOUNDS AND USES THEREOF JANSSEN PHARMACEUTICA NV (BE) 2023-03-16 US disclosed
EP-3941908-A1 COMPOUNDS AND USES THEREOF Yumanity Therapeutics, Inc. (US) 2022-01-26 EP disclosed
WO-2020198026-A1 COMPOUNDS AND USES THEREOF YUMANITY THERAPEUTICS, INC. (US) 2020-10-01 WO disclosed
WO-2019183587-A1 COMPOUNDS AND USES THEREOF YUMANITY THERAPEUTICS, INC. (US) 2019-09-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12612396-B1 Modulators of beta catenin and uses thereof CTNNB1, CTNND1, CTNNA1 P2RY2 4395/4885FFAR2 4798/4885CCNE1 447/4885
US-20230078764-A1 COMPOUNDS AND USES THEREOF NLN, BDNF, NQO1 P2RY2 2029/4885FFAR2 4354/4885CCNE1 2527/4885
US-20260138977-A1 MODULATORS OF BETA CATENIN AND USES THEREOF CTNNB1, CTNND1, CTNNA1 P2RY2 4395/4885FFAR2 4798/4885CCNE1 447/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.