Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21394609 | 0.77 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNABRD9ATMTDP2 | |
| SCHEMBL21395095 | 0.75 | TLR9 (0.36) | SMN1; SMN2LMNAKMT2ACRHR1ALDH1A1 | |
| SCHEMBL9203781 | 0.72 | PDE4B (0.37) | PDE3APDE4BPDE10A | |
| SCHEMBL21384203 | 0.71 | GPR35 (0.44) | SMN1; SMN2LMNAATMALDH1A1 | |
| SCHEMBL18538394 | 0.67 | CREBBP (0.46) | SMN1; SMN2BRD9HDAC4HDAC8CREBBP | |
| SCHEMBL28786095 | 0.66 | ENPP1 (0.44) | SMN1; SMN2LMNABRD9ATMPDE3A | |
| SCHEMBL25925464 | 0.66 | TDP2 (0.43) | SMN1; SMN2LMNABRD9TDP2MAPT | |
| SCHEMBL24393050 | 0.66 | PDE10A (0.49) | SMN1; SMN2LMNABRD9PDE3ATDP2 | |
| SCHEMBL22031949 | 0.66 | KAT2B (0.39) | SMN1; SMN2BRD9ATMPDE3ACREBBP | |
| SCHEMBL22016469 | 0.66 | PDE3B (0.45) | SMN1; SMN2HDAC4HDAC8PDE3APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |