Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21394865 | 0.90 | NR3C2 (0.47) | GRM5WNT3ANPC1RAB9ATP53 | |
| SCHEMBL29358065 | 0.90 | NR3C2 (0.47) | GRM5WNT3ANPC1RAB9ATP53 | |
| SCHEMBL21394779 | 0.90 | GPR6 (0.41) | GRM5 | |
| SCHEMBL29356981 | 0.90 | GPR6 (0.41) | GRM5 | |
| SCHEMBL21395082 | 0.88 | NPC1 (0.43) | GRM5WNT3ACYP1A2CYP2C9KDM4E | |
| SCHEMBL22479673 | 0.86 | NPC1 (0.47) | GRM5CYP1A2CYP2C9CYP3A4NPC1 | |
| SCHEMBL29353664 | 0.83 | GRM4 (0.43) | GRM5WNT3ANPC1RAB9A | |
| SCHEMBL21395200 | 0.83 | GRM4 (0.43) | GRM5WNT3ANPC1RAB9A | |
| SCHEMBL21394613 | 0.83 | ALDH1A1 (0.48) | NPC1RAB9AHCRTR1TP53MAPT | |
| SCHEMBL29357133 | 0.83 | ALDH1A1 (0.48) | NPC1RAB9AHCRTR1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |