Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.53 |
| ▸ | GRM5 | P41594 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | GCK | P35557 | 2/20 | 0.45 |
| ▸ | RARG | P13631 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21395077 | 0.93 | GCK (0.51) | CYP3A4GRM5MEN1KMT2AGCK | |
| SCHEMBL29355464 | 0.87 | RAB9A (0.47) | CYP3A4GRM5MEN1NPC1CASP3 | |
| SCHEMBL21394840 | 0.87 | RAB9A (0.47) | CYP3A4GRM5MEN1NPC1CASP3 | |
| SCHEMBL21394862 | 0.86 | GCK (0.52) | MEN1NPC1CASP3RAB9AKMT2A | |
| SCHEMBL29357283 | 0.86 | GCK (0.52) | MEN1NPC1CASP3RAB9AKMT2A | |
| SCHEMBL29354520 | 0.86 | MEN1 (0.53) | GRM5MEN1NPC1CASP3RAB9A | |
| SCHEMBL21394759 | 0.86 | MEN1 (0.53) | GRM5MEN1NPC1CASP3RAB9A | |
| SCHEMBL21395088 | 0.86 | MEN1 (0.44) | CYP3A4GRM5MEN1NPC1CASP3 | |
| SCHEMBL21395070 | 0.83 | CYP3A4 (0.49) | CYP3A4GRM5CYP1A2CYP2C9 | |
| SCHEMBL21395157 | 0.77 | CYP3A4 (0.47) | CYP3A4GRM5GCKRARGCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |