Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3469523 | 0.87 | RXRA (0.33) | ALDH1A1HTTCA2CAMK2A | |
| SCHEMBL12808556 | 0.69 | ALDH1A1 (0.37) | ALDH1A1HTTKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL11799159 | 0.68 | GAA (0.31) | — | |
| SCHEMBL2862352 | 0.68 | KDM4E (0.40) | ALDH1A1KDM4E | |
| SCHEMBL20359277 | 0.67 | AKR1B1 (0.50) | ALDH1A1KDM4EHPGDAKR1B1 | |
| SCHEMBL10721635 | 0.67 | POLB (0.39) | ALDH1A1HTTKDM4EHPGDCA2 | |
| SCHEMBL9785266 | 0.67 | POLB (0.32) | CA2CAMK2AAKR1B1 | |
| SCHEMBL13952188 | 0.66 | ALDH1A1 (0.36) | ALDH1A1HTTKDM4EHPGDSMN1; SMN2 | |
| Propionic Acid SCHEMBL28491340 | 0.65 | FFAR3 (0.42) | ALDH1A1 | |
| SCHEMBL9616985 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148568-B2 | Esters of (2-hydroxy-3-oxo-cyclopent-1-enyl) acetic acid and their use for preparing (−)-R-homocitric acid gamma-lactone, (+)-S-homocitric acid gamma-lactone and the corresponding (−)-R-homocitric acid and (+)-S-homocitric acid salts | TALLINN UNIVERSITY OF TECHNOLOGY (EE) | 2012-04-03 | — | — | US | claimed |
| US-20090187041-A1 | ESTERS OF (2-HYDROXY-3-OXO-CYCLOPENT-1-ENYL) ACETIC ACID AND THEIR USE FOR PREPARING (-)-R-HOMOCITRIC ACID GAMMA-LACTONE, (+)-S-HOMOCITRIC ACID GAMMA-LACTONE AND THE CORRESPONDING (-)-R-HOMOCITRIC ACID AND (+)-S-HOMOCITRIC ACID SALTS | TALLINN UNIVERSITY OF TECHNOLOGY (EE) | 2009-07-23 | — | — | US | claimed |
| US-8148568-B2 | Esters of (2-hydroxy-3-oxo-cyclopent-1-enyl) acetic acid and their use for preparing (−)-R-homocitric acid gamma-lactone, (+)-S-homocitric acid gamma-lactone and the corresponding (−)-R-homocitric acid and (+)-S-homocitric acid salts | TALLINN UNIVERSITY OF TECHNOLOGY (EE) | 2012-04-03 | — | — | US | disclosed |
| US-8148568-B2 | Esters of (2-hydroxy-3-oxo-cyclopent-1-enyl) acetic acid and their use for preparing (−)-R-homocitric acid gamma-lactone, (+)-S-homocitric acid gamma-lactone and the corresponding (−)-R-homocitric acid and (+)-S-homocitric acid salts | TALLINN UNIVERSITY OF TECHNOLOGY (EE) | 2012-04-03 | — | — | US | disclosed |
| US-20090187041-A1 | ESTERS OF (2-HYDROXY-3-OXO-CYCLOPENT-1-ENYL) ACETIC ACID AND THEIR USE FOR PREPARING (-)-R-HOMOCITRIC ACID GAMMA-LACTONE, (+)-S-HOMOCITRIC ACID GAMMA-LACTONE AND THE CORRESPONDING (-)-R-HOMOCITRIC ACID AND (+)-S-HOMOCITRIC ACID SALTS | TALLINN UNIVERSITY OF TECHNOLOGY (EE) | 2009-07-23 | — | — | US | disclosed |
| WO-2007137593-A1 | ESTERS OF (2-HYDROXY-3-OXO-CYCLOPENT-1-ENYL) ACETIC ACID AND THEIR USE FOR PREPARING (-)-R-HOMOCITRIC ACID GAMMA-LACTONE, (+)-S-HOMOCITRIC ACID GAMMA-LACTONE AND THE CORRESPONDING (-)-R-HOMOCITRIC ACID AND (+)-S-HOMOCITRIC ACID SALTS | TALLINN UNIVERSITY OF TECHNOLOGY (EE) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090187041-A1 | ESTERS OF (2-HYDROXY-3-OXO-CYCLOPENT-1-ENYL) ACETIC ACID AND THEIR USE FOR PREPARING (-)-R-HOMOCITRIC ACID GAMMA-LACTONE, (+)-S-HOMOCITRIC ACID GAMMA-LACTONE AND THE CORRESPONDING (-)-R-HOMOCITRIC ACID AND (+)-S-HOMOCITRIC ACID SALTS | HACL2, CYP8B1, HCAR1 | ALDH1A1 359/4885HTT 243/4885KDM4E 4301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.