Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.69 |
| ▸ | RELA | Q04206 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 5/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14046922 | 0.91 | NFKB1 (0.71) | NFKB1NFKB2RELAABL1ABCC4 | |
| SCHEMBL2141296 | 0.84 | NFKB1 (0.72) | NFKB1NFKB2RELAABL1ABCC4 | |
| SCHEMBL2139370 | 0.82 | NFKB1 (1.00) | NFKB1NFKB2RELAABL1ABCC4 | |
| SCHEMBL30316128 | 0.82 | NFKB1 (1.00) | NFKB1NFKB2RELAABL1ABCC4 | |
| SCHEMBL27735776 | 0.82 | NFKB1 (0.70) | NFKB1NFKB2RELAABL1ABCC4 | |
| SCHEMBL2139185 | 0.82 | NFKB1 (0.66) | NFKB1NFKB2RELAABL1ABCC4 | |
| SCHEMBL2137790 | 0.80 | NFKB1 (0.78) | NFKB1NFKB2RELAABL1ABCC4 | |
| SCHEMBL2140250 | 0.79 | NFKB1 (0.57) | NFKB1NFKB2RELAIRAK4SCD | |
| SCHEMBL2142554 | 0.79 | NFKB1 (0.66) | NFKB1NFKB2RELAABL1ABCC4 | |
| SCHEMBL2138598 | 0.78 | NFKB1 (0.67) | NFKB1NFKB2RELAABL1ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110052532-A1 | Pharmaceutical composition comprising a cytokine | STROBL STEFAN | 2011-03-03 | — | — | US | disclosed |
| US-20110052532-A1 | Pharmaceutical composition comprising a cytokine | STROBL STEFAN | 2011-03-03 | — | — | US | disclosed |
| US-20110052532-A1 | Pharmaceutical composition comprising a cytokine | STROBL STEFAN | 2011-03-03 | — | — | US | disclosed |
| CN-101405278-A | Novel heterocyclic NF-kB inhibitors | 4SC AG (DE) | 2009-04-08 | — | — | CN | disclosed |
| EP-1977759-A1 | Pharmaceutical composition comprising a cytokine | 4SC AG (DE) | 2008-10-08 | — | — | EP | disclosed |
| US-20080241100-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A CYTOKINE | 4SC AG (DE) | 2008-10-02 | — | — | US | disclosed |
| US-20080241100-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A CYTOKINE | 4SC AG (DE) | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110052532-A1 | Pharmaceutical composition comprising a cytokine | IL2, IL17A, IFNG | NFKB1 348/4885NFKB2 161/4885RELA 616/4885 |
| US-20080241100-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A CYTOKINE | IL2, IL17A, IFNG | NFKB1 348/4885NFKB2 161/4885RELA 616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.