Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21384617 | 0.83 | L3MBTL1 (0.51) | KDM4EKMT2AL3MBTL1GAAMEN1 | |
| SCHEMBL21385141 | 0.83 | MAPT (0.45) | NOTUMKDM4ECYP2C9CYP2C19GPR119 | |
| SCHEMBL18155148 | 0.82 | L3MBTL1 (0.50) | NOTUMKDM4ECYP2C9CYP2C19GPR119 | |
| SCHEMBL12988320 | 0.80 | L3MBTL1 (0.52) | NOTUMKDM4EKMT2AMBTD1L3MBTL3 | |
| SCHEMBL22552788 | 0.80 | NOTUM (0.50) | NOTUMCYP2C9CYP2C19GPR119USP2 | |
| SCHEMBL2557623 | 0.80 | NOTUM (0.50) | NOTUMCYP2C9CYP2C19GPR119USP2 | |
| SCHEMBL9027649 | 0.79 | L3MBTL1 (0.50) | NOTUMKDM4ECYP2C9CYP2C19KMT2A | |
| SCHEMBL9785724 | 0.78 | ACHE (0.64) | KDM4EKMT2AL3MBTL3L3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL28444516 | 0.77 | L3MBTL1 (0.49) | NOTUMKDM4ECYP2C9CYP2C19KMT2A | |
| SCHEMBL20825649 | 0.77 | POLB (0.46) | NOTUMKDM4ECYP2C9CYP2C19GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117185987-A | Amidine and guanidine derivatives, preparation method and medical application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-111630048-B | Amidine and guanidine derivatives, preparation method and medical application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-111630048-A | Amidine and guanidine derivatives, preparation method and application thereof in medicines | 四川科伦博泰生物医药股份有限公司 | 2020-09-04 | — | — | CN | disclosed |
| WO-2019179362-A1 | AMIDINE AND GUANIDINE DERIVATIVES, PREPARATION METHOD THEREFOR AND MEDICAL USES THEREOF | 四川科伦博泰生物医药股份有限公司 | 2019-09-26 | — | — | WO | disclosed |