Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21397670 | 0.76 | HTR2A (0.33) | DRD2OPRK1 | |
| SCHEMBL24388797 | 0.73 | SLC6A2 (0.39) | DRD2BACE1OTUD7BPDK2SLC6A2 | |
| SCHEMBL23024527 | 0.68 | OTUD7B (0.38) | DRD2OPRD1BACE1OTUD7BPDK2 | |
| SCHEMBL24388827 | 0.68 | DRD2 (0.41) | DRD2OPRD1OPRK1BACE1OTUD7B | |
| SCHEMBL30529476 | 0.68 | OTUD7B (0.38) | DRD2OPRD1BACE1OTUD7BPDK2 | |
| Hydrochloric Acid SCHEMBL23024386 | 0.67 | OTUD7B (0.38) | DRD2OPRD1BACE1OTUD7BPDK2 | |
| SCHEMBL21397337 | 0.66 | HTR2A (0.37) | SLC6A2SLC6A4 | |
| SCHEMBL21397254 | 0.65 | DRD2 (0.32) | DRD2 | |
| SCHEMBL13131168 | 0.64 | ACHE (0.59) | DRD2PDK2 | |
| SCHEMBL11931918 | 0.64 | DRD2 (0.36) | DRD2OPRD1BACE1OTUD7BPDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183367-A1 | SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |