Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | STING1 | Q86WV6 | 4/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | LHCGR | P22888 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30416042 | 1.00 | ALDH1A1 (0.39) | ALDH1A1STING1CSNK2A2KDRCSNK2B | |
| SCHEMBL24175693 | 0.86 | CSNK2A2 (0.47) | ALDH1A1STING1CSNK2A2KDRCSNK2B | |
| SCHEMBL30416428 | 0.84 | STING1 (0.44) | STING1CSNK2A2KDRCSNK2BCSNK2A1 | |
| SCHEMBL21405800 | 0.84 | STING1 (0.44) | STING1CSNK2A2KDRCSNK2BCSNK2A1 | |
| SCHEMBL21405827 | 0.81 | STING1 (0.45) | ALDH1A1STING1CSNK2A2KDRCSNK2B | |
| SCHEMBL21454852 | 0.81 | STING1 (0.33) | STING1 | |
| SCHEMBL30416399 | 0.79 | STING1 (0.58) | ALDH1A1STING1 | |
| SCHEMBL21406360 | 0.79 | STING1 (0.58) | ALDH1A1STING1 | |
| SCHEMBL21454855 | 0.78 | STING1 (0.35) | STING1 | |
| SCHEMBL21454857 | 0.77 | STING1 (0.44) | STING1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702430-B2 | Aza-benzothiophene compounds as STING agonists | MERCK SHARP & DOHME LLC (US) | 2023-07-18 | — | — | US | disclosed |
| US-11702430-B2 | Aza-benzothiophene compounds as STING agonists | MERCK SHARP & DOHME LLC (US) | 2023-07-18 | — | — | US | disclosed |
| US-11702430-B2 | Aza-benzothiophene compounds as STING agonists | MERCK SHARP & DOHME LLC (US) | 2023-07-18 | — | — | US | disclosed |
| EP-3774765-A1 | AZA-BENZOTHIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2021-02-17 | — | — | EP | disclosed |
| US-20210009608-A1 | AZA-BENZOTHIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2021-01-14 | — | — | US | disclosed |
| US-20210009608-A1 | AZA-BENZOTHIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2021-01-14 | — | — | US | disclosed |
| CN-111971277-A | Benzothiophenes and related compounds as STING agonists | 默沙东公司 | 2020-11-20 | — | — | CN | disclosed |
| US-10793557-B2 | Sting agonist compounds | MERCK SHARP & DOHME CORP. (US) | 2020-10-06 | — | — | US | disclosed |
| US-10793557-B2 | Sting agonist compounds | MERCK SHARP & DOHME CORP. (US) | 2020-10-06 | — | — | US | disclosed |
| WO-2019195124-A1 | BENZOTHIOPHENES AND RELATED COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2019-10-10 | — | — | WO | disclosed |
| WO-2019195063-A1 | AZA-BENZOTHIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2019-10-10 | — | — | WO | disclosed |
| WO-2019195063-A1 | AZA-BENZOTHIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2019-10-10 | — | — | WO | disclosed |
| US-20190300513-A1 | STING AGONIST COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2019-10-03 | — | — | US | disclosed |
| US-20190300513-A1 | STING AGONIST COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2019-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190300513-A1 | STING AGONIST COMPOUNDS | STING1, CGAS, IRF3 | ALDH1A1 4795/4885STING1 1/4885CSNK2A2 835/4885 |
| US-10793557-B2 | Sting agonist compounds | STING1, CGAS, IRF3 | ALDH1A1 4795/4885STING1 1/4885CSNK2A2 835/4885 |
| US-11702430-B2 | Aza-benzothiophene compounds as STING agonists | STING1, IRF3, CGAS | ALDH1A1 3651/4885STING1 1/4885CSNK2A2 2250/4885 |
| US-20210009608-A1 | AZA-BENZOTHIOPHENE COMPOUNDS AS STING AGONISTS | STING1, IRF3, CGAS | ALDH1A1 3651/4885STING1 1/4885CSNK2A2 2250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.