Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21408160 | 0.91 | CTSK (0.38) | KDM1AUSP2SMN1; SMN2CTSKALDH1A1 | |
| SCHEMBL25307149 | 0.83 | KDM1A (0.39) | KDM1AUSP2SMN1; SMN2CTSKALDH1A1 | |
| SCHEMBL21408128 | 0.83 | KDM1A (0.40) | KDM1AUSP2SMN1; SMN2CTSKALDH1A1 | |
| SCHEMBL479856 | 0.80 | KDM1A (0.43) | KDM1AUSP2SMN1; SMN2CTSKALDH1A1 | |
| SCHEMBL21408149 | 0.79 | KDM1A (0.41) | KDM1AUSP2SMN1; SMN2CTSKNR1H2 | |
| SCHEMBL21408133 | 0.78 | KDM1A (0.40) | KDM1AUSP2SMN1; SMN2CTSKPDE4A | |
| SCHEMBL21408157 | 0.76 | — | — | |
| SCHEMBL21408167 | 0.76 | KDM1A (0.36) | KDM1AUSP2SMN1; SMN2CTSKPDE4A | |
| SCHEMBL25311521 | 0.75 | KDM1A (0.36) | KDM1A | |
| SCHEMBL3733424 | 0.72 | KDM1A (0.42) | KDM1AUSP2SMN1; SMN2CTSKALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110573500-B | N- (nitrogen heterocyclic aryl) lactam-1-formamide derivative and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2020-12-08 | — | — | CN | disclosed |
| CN-110573500-A | N- (nitrogen heterocyclic aryl) lactam-1-formamide derivative and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2019-12-13 | — | — | CN | disclosed |
| WO-2018214867-A9 | N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2019-10-03 | — | — | WO | disclosed |