⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21408124 | 0.76 | KDM1A (0.41) | — | |
| SCHEMBL21426306 | 0.75 | CSF1R (0.31) | — | |
| SCHEMBL21408172 | 0.73 | — | — | |
| SCHEMBL21408160 | 0.67 | CTSK (0.38) | — | |
| SCHEMBL28745680 | 0.61 | NOTUM (0.39) | — | |
| SCHEMBL2120814 | 0.60 | FFAR3 (0.32) | — | |
| SCHEMBL21425520 | 0.59 | CSF1R (0.31) | — | |
| SCHEMBL11826368 | 0.56 | LMNA (0.30) | — | |
| SCHEMBL18919932 | 0.56 | SPR (0.38) | — | |
| SCHEMBL16240342 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115385897-B | Preparation method of CSF-1R inhibitor or acid salt thereof | 上海和誉生物医药科技有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-115385897-A | Preparation method of CSF-1R inhibitor or acid salt thereof | 上海和誉生物医药科技有限公司 | 2022-11-25 | — | — | CN | disclosed |
| CN-110573500-B | N- (nitrogen heterocyclic aryl) lactam-1-formamide derivative and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2020-12-08 | — | — | CN | disclosed |
| CN-110573500-A | N- (nitrogen heterocyclic aryl) lactam-1-formamide derivative and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2019-12-13 | — | — | CN | disclosed |
| WO-2018214867-A9 | N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2019-10-03 | — | — | WO | disclosed |