Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.37 |
| ▸ | CSF1R | P07333 | 8/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.34 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21772010 | 0.85 | GABRP (0.40) | TGFBR1CSF1RPDGFRAPDGFRBCYP2C9 | |
| SCHEMBL21408136 | 0.84 | TGFBR1 (0.36) | TGFBR1CSF1RPDGFRAPDGFRBCYP2C9 | |
| SCHEMBL21408154 | 0.79 | TGFBR1 (0.37) | TGFBR1CSF1RPDGFRAPDGFRBCYP2C9 | |
| SCHEMBL3937375 | 0.76 | CCR1 (0.41) | USP30AAK1 | |
| SCHEMBL27116699 | 0.76 | TGFBR1 (0.35) | TGFBR1CSF1RPDGFRAPDGFRBGABRP | |
| SCHEMBL29417518 | 0.75 | USP30 (0.39) | USP30AAK1 | |
| SCHEMBL30890847 | 0.75 | CSF1R (0.61) | CSF1RPDGFRAPDGFRBCYP2C9FLT3 | |
| SCHEMBL21408138 | 0.75 | CSF1R (0.61) | CSF1RPDGFRAPDGFRBCYP2C9FLT3 | |
| SCHEMBL828662 | 0.74 | NPC1 (0.42) | USP30AAK1 | |
| SCHEMBL29992185 | 0.73 | USP30 (0.45) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3632907-B1 | N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2024-02-28 | — | — | EP | disclosed |
| WO-2018214867-A9 | N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2019-10-03 | — | — | WO | disclosed |