Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 7/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21409023 | 1.00 | CYP2A6 (0.44) | CYP2A6CYP3A4CCNT1CDK9HASPIN | |
| SCHEMBL255443 | 0.77 | CYP2A6 (0.56) | CYP2A6CYP3A4CCNT1CDK9HASPIN | |
| SCHEMBL16693057 | 0.75 | CYP2A6 (0.58) | CYP2A6KDM4EHPGDGFERSMN1; SMN2 | |
| SCHEMBL533466 | 0.75 | CYP2A6 (0.58) | CYP2A6KDM4EHPGDGFERSMN1; SMN2 | |
| SCHEMBL16684695 | 0.71 | APP (0.48) | CYP2A6KDM4EHPGDGFERSMN1; SMN2 | |
| SCHEMBL16684694 | 0.71 | APP (0.48) | CYP2A6KDM4EHPGDGFERSMN1; SMN2 | |
| SCHEMBL16693152 | 0.68 | APP (0.48) | CYP2A6KDM4EHPGDGFERSMN1; SMN2 | |
| SCHEMBL16684587 | 0.68 | APP (0.48) | CYP2A6KDM4EHPGDGFERSMN1; SMN2 | |
| SCHEMBL6488493 | 0.68 | KMT2A (0.46) | KDM4EHPGDMAPTPRMT1MEN1 | |
| SCHEMBL6488496 | 0.68 | KMT2A (0.46) | KDM4EHPGDMAPTPRMT1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12336991-B2 | Factor XIIA inhibitors | UNIVERSITY OF LEEDS (GB) | 2025-06-24 | — | — | US | disclosed |
| US-20220305011-A1 | FACTOR XIIA INHIBITORS | UNIVERSITY OF LEEDS (GB) | 2022-09-29 | — | — | US | disclosed |
| EP-3773555-A1 | FACTOR XIIA INHIBITORS | University of Leeds (GB) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019186164-A1 | FACTOR XIIA INHIBITORS | UNIVERSITY OF LEEDS (GB) | 2019-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220305011-A1 | FACTOR XIIA INHIBITORS | F11, F13B, F12 | CYP2A6 624/4885CYP3A4 248/4885CCNT1 2281/4885 |
| US-12336991-B2 | Factor XIIA inhibitors | F11, F13B, F12 | CYP2A6 624/4885CYP3A4 248/4885CCNT1 2281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.