Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CD69 | Q07108 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.41 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.41 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PYGB | P11216 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24768349 | 0.89 | ALDH1A1 (0.53) | MAPK1ALDH1A1THRBCD69SMN1; SMN2 | |
| SCHEMBL3295284 | 0.89 | MAPK1 (0.65) | MAPK1ALDH1A1THRBCD69SMN1; SMN2 | |
| SCHEMBL3296000 | 0.89 | MAPK1 (0.65) | MAPK1ALDH1A1THRBCD69SMN1; SMN2 | |
| SCHEMBL6944012 | 0.89 | MAPK1 (0.65) | MAPK1ALDH1A1THRBCD69SMN1; SMN2 | |
| SCHEMBL23478019 | 0.89 | MAPK1 (0.65) | MAPK1ALDH1A1THRBCD69SMN1; SMN2 | |
| SCHEMBL21947408 | 0.89 | MAPK1 (0.65) | MAPK1ALDH1A1THRBCD69SMN1; SMN2 | |
| SCHEMBL3295282 | 0.89 | MAPK1 (0.65) | MAPK1ALDH1A1THRBCD69SMN1; SMN2 | |
| SCHEMBL6942761 | 0.89 | MAPK1 (0.65) | MAPK1ALDH1A1THRBCD69SMN1; SMN2 | |
| SCHEMBL3295994 | 0.89 | MAPK1 (0.65) | MAPK1ALDH1A1THRBCD69SMN1; SMN2 | |
| SCHEMBL23848966 | 0.88 | MAPK1 (0.61) | MAPK1ALDH1A1THRBCD69SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608406-B1 | COMPOSITIONS AND METHODS FOR MODULATING COMPLEMENT FACTOR B EXPRESSION | IONIS PHARMACEUTICALS INC (US) | 2023-02-15 | — | — | EP | disclosed |
| EP-3137091-B1 | CONJUGATES OF MODIFIED ANTISENSE OLIGONUCLEOTIDES AND THEIR USE FOR MODULATING PKK EXPRESSION | IONIS PHARMACEUTICALS INC (US) | 2020-12-02 | — | — | EP | disclosed |
| EP-3690049-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION | Ionis Pharmaceuticals, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |
| EP-3546579-A1 | CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE | Ionis Pharmaceuticals, Inc. (US) | 2019-10-02 | — | — | EP | disclosed |