Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 11/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.38 |
| ▸ | LTA4H | P09960 | 6/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2142978 | 0.94 | ADRB2 (0.42) | ADRB2CHRM3ADRB1LTA4HDRD3 | |
| SCHEMBL2142994 | 0.94 | ADRB2 (0.42) | ADRB2CHRM3ADRB1LTA4HDRD3 | |
| SCHEMBL10242576 | 0.89 | ADRB2 (0.50) | ADRB2CHRM3ADRB1DRD3DRD2 | |
| Formic Acid SCHEMBL2142446 | 0.88 | ADRB2 (0.49) | ADRB2CHRM3ADRB1DRD3DRD2 | |
| Formic Acid SCHEMBL2142418 | 0.88 | ADRB2 (0.49) | ADRB2CHRM3ADRB1DRD3DRD2 | |
| SCHEMBL2139288 | 0.87 | CHRM3 (0.44) | ADRB2CHRM3ADRB1DRD3CHRM2 | |
| SCHEMBL2142281 | 0.86 | ADRB2 (0.45) | ADRB2CHRM3ADRB1DRD3DRD2 | |
| SCHEMBL2141745 | 0.86 | ADRB2 (0.48) | ADRB2CHRM3ADRB1DRD3CHRM2 | |
| SCHEMBL2143037 | 0.85 | CHRM3 (0.50) | ADRB2CHRM3ADRB1DRD3CHRM2 | |
| SCHEMBL2141253 | 0.85 | ADRB2 (0.61) | ADRB2CHRM3ADRB1DRD3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629271-B2 | Compounds | ASTRAZENECA AB (GB) | 2014-01-14 | — | — | US | disclosed |
| US-20120322788-A1 | Compouds | PULMAGEN THERAPEUTICS (SYNERGY) LIMITED (GB) | 2012-12-20 | — | — | US | disclosed |
| EP-2242759-B1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2012-09-12 | — | — | EP | disclosed |
| US-8148373-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-04-03 | — | — | US | disclosed |
| US-20090298807-A1 | Compounds | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322788-A1 | Compouds | PKD1, SBDS, ABCB11 | ADRB2 1366/4885CHRM3 4265/4885ADRB1 970/4885 |
| US-20090298807-A1 | Compounds | PKD1, SLC10A1, ABCB11 | ADRB2 218/4885CHRM3 2714/4885ADRB1 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.