Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.47 |
| ▸ | HTR3A | P46098 | 4/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.38 |
| ▸ | WNT3A | P56704 | 2/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21417242 | 0.91 | CHRNA7 (0.47) | CHRNA7HTR3ANAMPTCTNNB1METAP2 | |
| SCHEMBL21417469 | 0.77 | CHRNA7 (0.51) | CHRNA7NPC1RAB9ALMNAMEN1 | |
| SCHEMBL21417095 | 0.76 | EPHX1 (0.47) | CHRNA7NPC1LMNAKDM4EMEN1 | |
| SCHEMBL21417098 | 0.75 | CHRNA7 (0.51) | CHRNA7HTR3AHDAC8METAP2NPC1 | |
| SCHEMBL20954560 | 0.73 | CHRNA7 (0.59) | CHRNA7HTR3ANAMPTCTNNB1WNT3A | |
| SCHEMBL20661376 | 0.72 | CHRNA7 (0.50) | CHRNA7HTR3ANPC1RAB9ADYRK1A | |
| SCHEMBL21417038 | 0.72 | CHRNA7 (0.50) | CHRNA7HTR3AHDAC8 | |
| SCHEMBL14879972 | 0.70 | HDAC8 (0.59) | CHRNA7HTR3ANAMPTHDAC8CTNNB1 | |
| SCHEMBL21417015 | 0.70 | CHRNA7 (0.52) | CHRNA7HTR3AHDAC8NPC1RAB9A | |
| SCHEMBL21417227 | 0.69 | MAOB (0.59) | CHRNA7NPC1RAB9ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233087-B1 | GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS | AXOVANT SCIENCES GMBH (DE) | 2019-10-02 | — | — | EP | disclosed |