Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 11/20 | 0.50 |
| ▸ | NPC1 | O15118 | 10/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21417242 | 0.79 | CHRNA7 (0.47) | CHRNA7RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL21417045 | 0.77 | CHRNA7 (0.47) | CHRNA7RAB9ANPC1LMNAMEN1 | |
| SCHEMBL21417227 | 0.74 | MAOB (0.59) | CHRNA7RAB9ANPC1LMNAMEN1 | |
| SCHEMBL21417095 | 0.73 | EPHX1 (0.47) | CHRNA7NPC1LMNAMEN1KMT2A | |
| SCHEMBL8566294 | 0.72 | RAB9A (0.68) | CHRNA7RAB9ANPC1LMNAMEN1 | |
| SCHEMBL21417331 | 0.71 | CHRNA7 (0.52) | CHRNA7 | |
| SCHEMBL21417098 | 0.70 | CHRNA7 (0.51) | CHRNA7RAB9ANPC1 | |
| SCHEMBL22850429 | 0.70 | RAB9A (0.65) | CHRNA7RAB9ANPC1LMNAMEN1 | |
| SCHEMBL20661376 | 0.69 | CHRNA7 (0.50) | CHRNA7RAB9ANPC1LMNAMEN1 | |
| SCHEMBL21417038 | 0.69 | CHRNA7 (0.50) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233087-B1 | GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS | AXOVANT SCIENCES GMBH (DE) | 2019-10-02 | — | — | EP | disclosed |