Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | WDR91 | A4D1P6 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21417045 | 0.76 | CHRNA7 (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL21417242 | 0.76 | CHRNA7 (0.47) | SMN1; SMN2LMNACHRNA7NPC1 | |
| SCHEMBL23130344 | 0.74 | IDO1 (0.58) | EPHX1P2RX7CCR1SMN1; SMN2HTT | |
| SCHEMBL21417098 | 0.74 | CHRNA7 (0.51) | CHRNA7NPC1HDAC1 | |
| SCHEMBL21417469 | 0.73 | CHRNA7 (0.51) | SMN1; SMN2HTTMEN1KMT2APOLB | |
| SCHEMBL21417023 | 0.70 | CHRNA7 (0.53) | CHRNA7HDAC1 | |
| SCHEMBL6878320 | 0.70 | CCR1 (0.40) | EPHX1P2RX7CCR1SMN1; SMN2MEN1 | |
| SCHEMBL21417227 | 0.69 | MAOB (0.59) | CCR1SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8303337 | 0.68 | EPHX1 (0.77) | EPHX1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL8185351 | 0.67 | HTT (0.65) | P2RX7SMN1; SMN2HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233087-B1 | GEMINAL SUBSTITUTED QUINUCLIDINE AMIDE COMPOUNDS AS AGONISTS OF ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTORS | AXOVANT SCIENCES GMBH (DE) | 2019-10-02 | — | — | EP | disclosed |