Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 4/20 | 0.53 |
| ▸ | GNPAT | O15228 | 2/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15810863 | 0.92 | ECE1 (0.50) | ECE1GNPATSIRT5KDM4EMAPT | |
| SCHEMBL12112082 | 0.92 | ECE1 (0.50) | ECE1GNPATSIRT5KDM4EMAPT | |
| SCHEMBL7003664 | 0.92 | ECE1 (0.50) | ECE1GNPATSIRT5KDM4EMAPT | |
| SCHEMBL13930092 | 0.90 | SIRT5 (0.47) | ECE1GNPATSIRT5CHRM2CHRM4 | |
| SCHEMBL13930086 | 0.90 | ECE1 (0.44) | ECE1GNPATSIRT5KDM4EMAPT | |
| SCHEMBL13930091 | 0.88 | ECE1 (0.47) | ECE1GNPATSIRT5CHRM2CHRM4 | |
| SCHEMBL14499478 | 0.84 | KDM4E (0.43) | ECE1GNPATSIRT5KDM4EMAPT | |
| SCHEMBL20244923 | 0.84 | KDM4E (0.43) | ECE1GNPATSIRT5KDM4EMAPT | |
| SCHEMBL13637922 | 0.84 | KDM4E (0.43) | ECE1GNPATSIRT5KDM4EMAPT | |
| SCHEMBL26019602 | 0.82 | GNPAT (0.41) | ECE1GNPATKDM4EMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787490-B2 | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases | Protaganist Therapeutics, Inc. (US) | 2020-09-29 | — | — | US | disclosed |
| US-20190300590-A1 | PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES | PROTAGONIST THERAPEUTICS, INC. | 2019-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190300590-A1 | PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES | IL23R, IL1RN, VIP | ECE1 1266/4885GNPAT 4170/4885SIRT5 3860/4885 |
| US-10787490-B2 | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases | IL23R, IL1RN, IL36G | ECE1 978/4885GNPAT 4123/4885SIRT5 4232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.