Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.55 |
| ▸ | PANK3 | Q9H999 | 9/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4215598 | 0.83 | HSD11B1 (0.57) | HSD11B1PANK3 | |
| SCHEMBL26502479 | 0.83 | PANK3 (0.54) | HSD11B1PANK3CNR2 | |
| SCHEMBL32675216 | 0.80 | KDM4E (0.64) | HSD11B1PANK3CHRM4CNR2EPHX2 | |
| SCHEMBL21406316 | 0.80 | PANK3 (0.57) | PANK3CHRM4CNR2 | |
| SCHEMBL1036229 | 0.79 | HSD11B1 (0.58) | HSD11B1EPHX2DPP4DPP8DPP9 | |
| SCHEMBL1036231 | 0.79 | HSD11B1 (0.58) | HSD11B1EPHX2DPP4DPP8DPP9 | |
| SCHEMBL21406054 | 0.77 | PANK3 (0.81) | PANK3CNR2 | |
| SCHEMBL32675217 | 0.77 | PANK3 (0.81) | PANK3CNR2 | |
| SCHEMBL21423853 | 0.76 | PANK3 (0.69) | PANK3CHRM4CNR2 | |
| SCHEMBL19748780 | 0.76 | PANK3 (0.69) | PANK3CHRM4CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025227071-A1 | METHODS AND COMPOSITIONS FOR TREATING HEART FAILURE AND LIVER DISEASE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2025-10-30 | — | — | WO | claimed |
| WO-2025227071-A1 | METHODS AND COMPOSITIONS FOR TREATING HEART FAILURE AND LIVER DISEASE | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2025-10-30 | — | — | WO | disclosed |
| US-20230321092-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. | 2023-10-12 | — | — | US | disclosed |
| US-11547709-B2 | Methods of treating disorders associated with castor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (US) | 2023-01-10 | — | — | US | disclosed |
| WO-2022133034-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (US) | 2022-06-23 | — | — | WO | disclosed |
| US-20210246113-A1 | SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. | 2021-08-12 | — | — | US | disclosed |
| US-20210023081-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. | 2021-01-28 | — | — | US | disclosed |
| US-20190300499-A1 | SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2019-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230321092-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR | HMGCR, GCDH, CYP11A1 | HSD11B1 56/4885PANK3 1573/4885CHRM4 3845/4885 |
| US-11547709-B2 | Methods of treating disorders associated with castor | HMGCR, GCDH, CYP11A1 | HSD11B1 56/4885PANK3 1573/4885CHRM4 3845/4885 |
| US-20210246113-A1 | SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES | PANK2, PANK1, PANK3 | HSD11B1 4379/4885PANK3 3/4885CHRM4 4525/4885 |
| US-20210023081-A1 | METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR | HMGCR, GCDH, CYP11A1 | HSD11B1 56/4885PANK3 1573/4885CHRM4 3845/4885 |
| US-20190300499-A1 | SMALL MOLECULE MODULATORS OF PANTOTHENATE KINASES | PANK2, PANK1, PANK3 | HSD11B1 4379/4885PANK3 3/4885CHRM4 4525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.