Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 12/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.34 |
| ▸ | SKP1 | P63208 | 1/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23011644 | 0.87 | PDK2 (0.39) | PDK2P2RX7HDAC4HDAC1HDAC6 | |
| SCHEMBL17579750 | 0.79 | PDK2 (0.41) | PDK2P2RX7KMT2AHDAC4HDAC1 | |
| SCHEMBL21423632 | 0.78 | P2RX7 (0.51) | PDK2P2RX7KMT2AHDAC4HDAC1 | |
| SCHEMBL23011648 | 0.78 | TGFBR1 (0.38) | PDK2P2RX7KMT2AHDAC4HDAC1 | |
| SCHEMBL21423961 | 0.77 | TGFBR1 (0.40) | PDK2P2RX7KMT2AHDAC4HDAC1 | |
| SCHEMBL24656040 | 0.77 | P2RX7 (0.39) | PDK2P2RX7KMT2AHDAC4HDAC1 | |
| SCHEMBL599712 | 0.77 | P2RX7 (0.53) | PDK2P2RX7KMT2AHDAC4HDAC1 | |
| SCHEMBL22916963 | 0.77 | PDK2 (0.39) | PDK2P2RX7HDAC4HDAC1HDAC6 | |
| SCHEMBL10233673 | 0.75 | CPB2 (0.43) | PDK2P2RX7KMT2AHDAC4HDAC1 | |
| SCHEMBL10183064 | 0.75 | PDK2 (0.43) | PDK2P2RX7KMT2AHDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778573-A1 | COMPOUND WITH ANTICANCER ACTIVITY | Kyowa Kirin Co., Ltd. (JP) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019189778-A1 | COMPOUND WITH ANTICANCER ACTIVITY | 協和発酵キリン株式会社 | 2019-10-03 | — | — | WO | disclosed |