Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.54 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.52 |
| ▸ | CPB2 | Q96IY4 | 8/20 | 0.47 |
| ▸ | GNPAT | O15228 | 1/20 | 0.43 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.42 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23011492 | 1.00 | FOLH1 (0.54) | FOLH1SLC6A5CPB2GNPATSLC15A2 | |
| SCHEMBL14599155 | 0.82 | CTSS (0.50) | CPB2 | |
| SCHEMBL19385942 | 0.81 | SLC6A5 (0.59) | FOLH1SLC6A5CPB2GNPATSLC15A2 | |
| SCHEMBL2494433 | 0.81 | SLC6A5 (0.59) | FOLH1SLC6A5CPB2GNPATSLC15A2 | |
| SCHEMBL2494432 | 0.81 | SLC6A5 (0.59) | FOLH1SLC6A5CPB2GNPATSLC15A2 | |
| SCHEMBL18272834 | 0.81 | FOLH1 (0.40) | FOLH1SLC6A5GNPATNOD1 | |
| SCHEMBL28620930 | 0.81 | SLC6A5 (0.53) | FOLH1SLC6A5CPB2GNPATSLC15A2 | |
| SCHEMBL24766211 | 0.81 | SLC6A5 (0.53) | FOLH1SLC6A5CPB2GNPATSLC15A2 | |
| SCHEMBL13127074 | 0.81 | MAPT (0.38) | FOLH1SLC6A5GNPATNOD1CA2 | |
| SCHEMBL1455498 | 0.81 | FOLH1 (0.62) | FOLH1SLC6A5CPB2GNPATSLC15A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11541049-B2 | Tetrahydroisoquinoline derivatives, preparation process and use thereof | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2023-01-03 | — | — | US | disclosed |
| US-20210052576-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES, PREPARATION PROCESS AND USE THEREOF | SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD. (CN) | 2021-02-25 | — | — | US | disclosed |
| WO-2019184744-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USES THEREOF | 四川科伦博泰生物医药股份有限公司 | 2019-10-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11541049-B2 | Tetrahydroisoquinoline derivatives, preparation process and use thereof | CYP3A4, CYP3A43, CYP11B2 | FOLH1 1828/4885SLC6A5 822/4885CPB2 1376/4885 |
| US-20210052576-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES, PREPARATION PROCESS AND USE THEREOF | CYP3A4, CYP3A43, CYP11B2 | FOLH1 1828/4885SLC6A5 822/4885CPB2 1376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.