Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dapsone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | MPO | P05164 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | PKM | P14618 | 2/20 | 0.70 |
| ▸ | CA1 | P00915 | 3/20 | 0.65 |
| ▸ | CA2 | P00918 | 3/20 | 0.65 |
| ▸ | CA12 | O43570 | 2/20 | 0.65 |
| ▸ | CA9 | Q16790 | 2/20 | 0.65 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | CA4 | P22748 | 1/20 | 0.65 |
| ▸ | CA6 | P23280 | 1/20 | 0.65 |
| ▸ | CA5A | P35218 | 1/20 | 0.65 |
| ▸ | CA7 | P43166 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10596934 | 1.00 | HTR6 (1.00) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL5055312 | 1.00 | HTR6 (1.00) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL1219599 | 1.00 | HTR6 (1.00) | HTR6TSHRCYP3A4LMNAMPO | |
| SCHEMBL324893 | 1.00 | HTR6 (1.00) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL9690514 | 0.97 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL11745790 | 0.97 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL28520980 | 0.97 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL27664082 | 0.97 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL2203636 | 0.97 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL9690505 | 0.97 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 72535 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117487536-B | Double-shell thermochromic microcapsule as well as preparation method and application thereof | Wuhan Zhongke Advanced Material Technology Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122080887-A | Underground autonomous net-forming plugging agent and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122080854-A | Organosilicon modified epoxy bi-component die-bonding adhesive and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122080736-A | Heat-resistant flame-retardant coating based on high-performance master batch, battery flame-retardant film and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122080397-A | Enzyme reactor based on amorphous Porous Organic Polymers (POPs), preparation method and application | — | 2026-05-26 | — | — | CN | claimed |
| CN-122074082-A | Polyimide film having improved breakdown characteristics and method for producing same | 聚酰亚胺尖端素材株式会社 | 2026-05-22 | — | — | CN | claimed |
| CN-122071606-A | High-performance epoxy resin and preparation method thereof | 大连理工大学 | 2026-05-22 | — | — | CN | claimed |
| WO-2026107113-A1 | MODIFIED CELLS FOR PROGRAMMING EXTRA ENVELOPED VIRUSES (EEVs) AND THEIR USE FOR PRODUCING THE EEVs, THE PROGRAMMED EEVs AND USES THEREOF | CALIDI BIOTHERAPEUTICS (NEVADA), INC. (US) | 2026-05-21 | — | — | WO | claimed |
| US-20260138973-A1 | SUBSTITUTED PYRIDINES FOR USE IN TREATING OR PREVENTING INFLAMMATORY DISEASES OR DISEASES ASSOCIATED WITH AN UNDESIRABLE IMMUNE RESPONSE | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| US-20260139160-A1 | ACQUISITION AND INTEGRATION ASSEMBLY OF BATTERY MODULE WITH FLAME-RETARDANT PROPERTY AND PREPARATION METHOD THEREOF | SHENZHEN YN TECH CO LTD (CN) | 2026-05-21 | — | — | US | claimed |
| US-4011361-A | COOKWARE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-03-08 | — | — | US | claimed |
| US-4005207-A | ISONICOTINIC ACID HYDRAZIDE, 2-PROPYL THIO-ISONICOTINAMIDE, 4,4'-DIAMINODIPHENYL SULFONE | SAARSTICKSTOFF-FATOL GMBH (DT) | 1977-01-25 | — | — | US | claimed |
| US-4003706-A | Method and reagents for the detection, estimation and quantitative determination of nitrate ions | BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH & DEVELOPMENT AUTHORITY (IL) | 1977-01-18 | — | — | US | claimed |
| US-3993072-A | Microporous drug delivery device | ALZA CORPORATION (US) | 1976-11-23 | — | — | US | claimed |
| US-3989610-A | ADHESIVES, PAINTS, PRINTED CIRCUITS, PLASTIC RELIEFS | HITACHI CHEMICAL COMPANY, LTD. (JA) | 1976-11-02 | — | — | US | claimed |
| US-3987230-A | GLASS FIBERS, EPOXY RESINS, PHENOLIC RESINS, PRINTED CIRCUITS | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JA) | 1976-10-19 | — | — | US | claimed |
| US-3975330-A | Imide-modified polyester resin and wire enamel containing the imide-modified polyester resin | NITTO ELECTRIC INDUSTRIAL CO., LTD. (JA) | 1976-08-17 | — | — | US | claimed |
| US-3966652-A | Method of making foamed copolyimides and product obtained therefrom | INTERNATIONAL HARVESTER COMPANY (US) | 1976-06-29 | — | — | US | claimed |
| US-3966726-A | Process for the production of cyclic carboxylic acid imides | AKZO N.V. (NL) | 1976-06-29 | — | — | US | claimed |
| US-3937685-A | THERMOSETTING RESINS FROM EPICHLOROHYDRIN AND DIHYDROXYCHALCONES | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-02-10 | — | — | US | claimed |