Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dapsone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.94 |
| ▸ | TSHR | P16473 | 3/20 | 0.94 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.94 |
| ▸ | LMNA | P02545 | 2/20 | 0.94 |
| ▸ | MPO | P05164 | 1/20 | 0.94 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.94 |
| ▸ | MEN1 | O00255 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | PKM | P14618 | 2/20 | 0.67 |
| ▸ | CA1 | P00915 | 3/20 | 0.62 |
| ▸ | CA2 | P00918 | 3/20 | 0.62 |
| ▸ | CA12 | O43570 | 2/20 | 0.62 |
| ▸ | CA9 | Q16790 | 2/20 | 0.62 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.62 |
| ▸ | AGO2 | Q9UKV8 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | CA4 | P22748 | 1/20 | 0.62 |
| ▸ | CA6 | P23280 | 1/20 | 0.62 |
| ▸ | CA5A | P35218 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dapsone SCHEMBL27664082 | 1.00 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO | |
| SCHEMBL324893 | 0.97 | HTR6 (1.00) | HTR6TSHRCYP3A4LMNAMPO | |
| SCHEMBL10596934 | 0.97 | HTR6 (1.00) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL21428 | 0.97 | HTR6 (1.00) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL1219599 | 0.97 | HTR6 (1.00) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL5055312 | 0.97 | HTR6 (1.00) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL9690505 | 0.94 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL11745790 | 0.94 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL9690514 | 0.94 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO | |
| Dapsone SCHEMBL28520980 | 0.94 | HTR6 (0.94) | HTR6TSHRCYP3A4LMNAMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1022301-B1 | Essentially colorless, transparent polyimide coatings and films | IST CORP (US) | 2004-04-28 | — | — | EP | claimed |
| EP-0593200-B1 | Method for preparing polyimides | GEN ELECTRIC (US) | 1997-05-28 | — | — | EP | claimed |
| WO-2014031923-A1 | COATED SUBSTRATES AND METHODS FOR PRODUCING THE SAME | MILLIKEN & COMPANY (US) | 2014-02-27 | — | — | WO | disclosed |
| US-20140058026-A1 | COATED SUBSTRATES AND METHODS FOR PRODUCING THE SAME | MILLIKEN & COMPANY (US) | 2014-02-27 | — | — | US | disclosed |
| US-7981996-B2 | reaction of a diamine such as ortho, meta or para-phenylenediamine with an anhydride like 3- or 4-chlorophthalic anhydride (3-ClPA) in the presence of a solvent (ortho dichlorobenzene) at a temperature above the normal boiling point of the solvent to produce bis/halophthalobisimide/; limited solubility | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2011-07-19 | — | — | US | disclosed |
| US-20080119660-A1 | reaction of a diamine such as ortho, meta or para-phenylenediamine with an anhydride like 3- or 4-chlorophthalic anhydride (3-ClPA) in the presence of a solvent (ortho dichlorobenzene) at a temperature above the normal boiling point of the solvent to produce bis/halophthalobisimide/; limited solubility | GENERAL ELECTRIC COMPANY (US) | 2008-05-22 | — | — | US | disclosed |
| US-5969079-A | HEAT RESISTANT, HIGH STRENGTH AEROSPACE ENGINEERING THERMOPLASTICS | THE BOEING COMPANY (US) | 1999-10-19 | — | — | US | disclosed |
| US-5756597-A | COMPOSITE; MIXTURE WITH A COMPATIBLE POLYMER | THE BOEING COMPANY (US) | 1998-05-26 | — | — | US | disclosed |
| US-5714566-A | CONDENSING DIAMINOPHENOL WITH LINEAR OR MULTIDIMENSIONAL INTERMEDIATE TO FORM BISAMINE, CONDENSING WITH ACID HALIDE | THE BOEING COMPANY (US) | 1998-02-03 | — | — | US | disclosed |
| US-5610317-A | CHEMICAL AND THERMAL PROPERTIES | THE BOEING COMPANY (US) | 1997-03-11 | — | — | US | disclosed |
| EP-0286214-A2 | Novel oligomeric diamine hardeners and their use for curing epoxy resin systems | AMOCO CORPORATION (US) | 1988-10-12 | — | — | EP | disclosed |
| US-4746718-A | Novel oligomeric diamine hardeners and their use for curing epoxy resin systems | AMOCO CORPORATION (US) | 1988-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119660-A1 | reaction of a diamine such as ortho, meta or para-phenylenediamine with an anhydride like 3- or 4-chlorophthalic anhydride (3-ClPA) in the presence of a solvent (ortho dichlorobenzene) at a temperature above the normal boiling point of the solvent to produce bis/halophthalobisimide/; limited solubility | DDT, DDC, DDAH1 | HTR6 1592/4885TSHR 4136/4885CYP3A4 391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.