Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30233844 | 0.87 | MFN2 (0.45) | ALDH1A1NPSR1HSD17B10OPRM1 | |
| SCHEMBL7804819 | 0.84 | MEN1 (0.55) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL30233620 | 0.82 | MFN2 (0.47) | ALDH1A1MEN1KMT2APOLBMAPK1 | |
| SCHEMBL30233529 | 0.79 | ALDH1A1 (0.47) | ALDH1A1NPSR1HSD17B10OPRM1 | |
| SCHEMBL5523733 | 0.78 | L3MBTL1 (0.59) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL5523736 | 0.78 | L3MBTL1 (0.59) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL10556520 | 0.78 | PKM (0.44) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL27268293 | 0.77 | MAPT (0.48) | ALDH1A1MEN1KMT2APKMALOX5 | |
| SCHEMBL17065542 | 0.76 | MEN1 (0.46) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL3541508 | 0.76 | L3MBTL1 (0.53) | ALDH1A1MEN1KMT2APOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019191470-A1 | HETEROBICYCLIC INHIBITORS OF MAT2A AND METHODS OF USE FOR TREATING CANCER | AGIOS PHARMACEUTICALS, INC. (US) | 2019-10-03 | — | — | WO | disclosed |