Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25862460 | 0.78 | TSHR (0.43) | TSHRKMT2AHSD17B10GAAMGAM | |
| SCHEMBL7303460 | 0.78 | TSHR (0.43) | TSHRKMT2AHSD17B10GAAMGAM | |
| SCHEMBL21797980 | 0.76 | DGAT1 (0.45) | TSHRKMT2AHSD17B10GAAMGAM | |
| SCHEMBL22735035 | 0.71 | TSHR (0.42) | TSHRKMT2AHSD17B10GAAMGAM | |
| SCHEMBL27318919 | 0.71 | TSHR (0.37) | TSHRKMT2AHSD17B10GAAMGAM | |
| SCHEMBL18312079 | 0.67 | — | — | |
| SCHEMBL15434694 | 0.67 | TSHR (0.42) | TSHRKMT2AHSD17B10GAAMGAM | |
| SCHEMBL15219030 | 0.67 | TDP1 (0.36) | HSD17B10LMNA | |
| SCHEMBL18963342 | 0.67 | NOS1 (0.33) | — | |
| SCHEMBL284164 | 0.66 | TSHR (0.53) | TSHRKMT2AHSD17B10GAAMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019185882-A1 | PHARMACEUTICAL COMPOUNDS | Opal Oncology Limited (GB) | 2019-10-03 | — | — | WO | disclosed |