Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 3/20 | 0.36 |
| ▸ | SIK1 | P57059 | 2/20 | 0.35 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.35 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21436091 | 0.89 | ALDH1A1 (0.47) | FGFR1ALDH1A1HTTHPGDMAPK1 | |
| SCHEMBL21436069 | 0.86 | FGFR1 (0.43) | FGFR1ALDH1A1HTTHPGDMAPK1 | |
| SCHEMBL19781251 | 0.84 | FGFR1 (0.58) | FGFR1ALDH1A1HTTHPGDMAPK1 | |
| SCHEMBL21436077 | 0.84 | RAB9A (0.42) | FGFR1ALDH1A1HTTHPGDMAPK1 | |
| SCHEMBL21436080 | 0.81 | GABRP (0.44) | FGFR1ALDH1A1HTTHPGDMAPK1 | |
| SCHEMBL19781569 | 0.80 | FGFR1 (0.51) | FGFR1ALDH1A1HTTHPGDMAPK1 | |
| SCHEMBL15213070 | 0.76 | FGFR1 (0.67) | FGFR1ALDH1A1HTTSIK1SIK2 | |
| SCHEMBL21436075 | 0.74 | ALDH1A1 (0.46) | FGFR1ALDH1A1HTTHPGDMAPK1 | |
| SCHEMBL21436072 | 0.74 | HPGD (0.48) | FGFR1ALDH1A1HTTHPGDMAPK1 | |
| SCHEMBL21436076 | 0.73 | RAB9A (0.50) | FGFR1ALDH1A1HTTHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352328-B2 | Heterocyclic compounds for the treatment of arenavirus | ARISAN THERAPEUTICS INC. (US) | 2022-06-07 | — | — | US | disclosed |
| US-20190308938-A1 | Heterocyclic Compounds for the Treatment of Arenavirus | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352328-B2 | Heterocyclic compounds for the treatment of arenavirus | C9, C1R, C1S | FGFR1 3928/4885ALDH1A1 1146/4885HTT 1337/4885 |
| US-20190308938-A1 | Heterocyclic Compounds for the Treatment of Arenavirus | C9, C1R, C1S | FGFR1 3928/4885ALDH1A1 1146/4885HTT 1337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.