Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2143723 | 0.81 | ALDH1A1 (0.63) | ALDH1A1ALOX12LMNAEGLN1 | |
| SCHEMBL2144202 | 0.79 | HSP90AA1 (0.55) | KDM4ETP53HSP90AA1MEN1KMT2A | |
| SCHEMBL2143785 | 0.78 | KDM4E (0.78) | KDM4ETP53HSP90AA1MEN1KMT2A | |
| SCHEMBL21902359 | 0.74 | KDM4E (0.59) | KDM4ETP53HSP90AA1MEN1KMT2A | |
| Broxyquinoline SCHEMBL28500050 | 0.73 | KDM4E (0.96) | KDM4ETP53HSP90AA1MEN1KMT2A | |
| SCHEMBL16794628 | 0.72 | HSP90AA1 (0.59) | HSP90AA1MEN1KMT2ATDP1SLC22A12 | |
| Broxyquinoline SCHEMBL115293 | 0.71 | KDM4E (1.00) | KDM4ETP53HSP90AA1MEN1KMT2A | |
| Broxyquinoline SCHEMBL30485535 | 0.71 | KDM4E (1.00) | KDM4ETP53HSP90AA1MEN1KMT2A | |
| Broxyquinoline SCHEMBL29607319 | 0.71 | KDM4E (1.00) | KDM4ETP53HSP90AA1MEN1KMT2A | |
| Broxyquinoline SCHEMBL31157810 | 0.70 | KDM4E (0.96) | KDM4ETP53HSP90AA1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | claimed |
| US-8729098-B2 | Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM SA (LU) | 2014-05-20 | — | — | US | claimed |
| US-20120309751-A1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2012-12-06 | — | — | US | claimed |
| EP-2345643-A1 | New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM S.A. (LU) | 2011-07-20 | — | — | EP | claimed |
| EP-2519505-B1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2015-05-27 | — | — | EP | disclosed |
| US-8729098-B2 | Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM SA (LU) | 2014-05-20 | — | — | US | disclosed |
| US-20120309751-A1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM SA (LU) | 2012-12-06 | — | — | US | disclosed |
| EP-2519505-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | Polichem SA (LU) | 2012-11-07 | — | — | EP | disclosed |
| EP-2345643-A1 | New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof | POLICHEM S.A. (LU) | 2011-07-20 | — | — | EP | disclosed |
| WO-2011080264-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM S.A. (LU) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309751-A1 | TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | TUBA8, SUCLG1, TUBB8 | KDM4E 2814/4885TP53 1727/4885HSP90AA1 1486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.