SCHEMBL2144200

SCHEMBL2144200

COC(=O)/C=C/C(=O)O[Si](C(C)CCl)(C(C)CCl)C(C)CCl

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 3/20 0.48
NFE2L2 Q16236 3/20 0.48
KEAP1 Q14145 1/20 0.48
GFPT1 Q06210 1/20 0.37
KDM4E B2RXH2 2/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPT P10636 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
LMNA P02545 1/20 0.30
HTT P42858 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
CA12 O43570 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
TYR P14679 1/20 0.30
CA7 P43166 1/20 0.30
CA9 Q16790 1/20 0.30
CA14 Q9ULX7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL475995 0.80 NFE2L2 (0.56) HCAR2NFE2L2KEAP1GFPT1KDM4E
SCHEMBL475876 0.80 NFE2L2 (0.56) HCAR2NFE2L2KEAP1GFPT1KDM4E
SCHEMBL475877 0.80 NFE2L2 (0.56) HCAR2NFE2L2KEAP1GFPT1KDM4E
SCHEMBL2144443 0.73 NFE2L2 (0.52) HCAR2NFE2L2KEAP1GFPT1KDM4E
SCHEMBL2144438 0.73 NFE2L2 (0.52) HCAR2NFE2L2KEAP1GFPT1KDM4E
SCHEMBL5974208 0.71 HCAR2 (0.39) HCAR2NFE2L2KEAP1
SCHEMBL5974213 0.71 HCAR2 (0.39) HCAR2NFE2L2KEAP1
SCHEMBL5974692 0.71 HCAR2 (0.39) HCAR2NFE2L2KEAP1
Dimethyl Maleate SCHEMBL75864 0.69 NFE2L2 (1.00) HCAR2NFE2L2KEAP1GFPT1KDM4E
Dimethyl Fumarate SCHEMBL11668350 0.69 NFE2L2 (1.00) HCAR2NFE2L2KEAP1GFPT1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2348077-B1 Antifouling composition JOTUN AS (NO) 2013-04-03 EP disclosed
WO-2011092143-A1 ANTIFOULING COMPOSITION JOTUN A/S (NO) 2011-08-04 WO disclosed
EP-2348077-A1 Antifouling composition Jotun A/S (NO) 2011-07-27 EP disclosed
EP-0802243-B1 Coating composition NOF CORP (JP) 2001-06-27 EP disclosed
US-5795374-A SILYL ACRYLATE POLYMERS NOF CORPORATION (JP) 1998-08-18 US disclosed
EP-0802243-A2 Coating composition NOF CORPORATION (JP) 1997-10-22 EP disclosed