SCHEMBL21445272

SCHEMBL21445272

CN1CCN(CCCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 10/20 1.00
LMNA P02545 6/20 0.96
MAPT P10636 6/20 0.96
SMN1; SMN2 Q16637 5/20 0.96
CYP3A4 P08684 4/20 0.96
MAPK1 P28482 4/20 0.96
TP53 P04637 3/20 0.96
RAD52 P43351 3/20 0.96
ALDH1A1 P00352 2/20 0.96
CYP1A2 P05177 2/20 0.96
ABCB1 P08183 2/20 0.96
HTR1A P08908 2/20 0.96
ADRA2A P08913 2/20 0.96
ADORA3 P0DMS8 2/20 0.96
CYP2D6 P10635 2/20 0.96
CHRM1 P11229 2/20 0.96
DRD2 P14416 2/20 0.96
ADRA2B P18089 2/20 0.96
ADRA2C P18825 2/20 0.96
NFKB1 P19838 2/20 0.96

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoperazine SCHEMBL29603012 0.98 FPR2 (1.00) FPR2LMNAMAPTSMN1; SMN2CYP3A4
Trifluoperazine SCHEMBL24866 0.98 FPR2 (1.00) FPR2LMNAMAPTSMN1; SMN2CYP3A4
Trifluoperazine SCHEMBL1897003 0.98 FPR2 (1.00) FPR2LMNAMAPTSMN1; SMN2CYP3A4
Trifluoperazine SCHEMBL41194 0.97 LMNA (1.00) FPR2LMNAMAPTSMN1; SMN2CYP3A4
Trifluoperazine SCHEMBL29430171 0.97 LMNA (1.00) FPR2LMNAMAPTSMN1; SMN2CYP3A4
Trifluoperazine SCHEMBL23039392 0.97 LMNA (1.00) FPR2LMNAMAPTSMN1; SMN2CYP3A4
Trifluoperazine SCHEMBL341516 0.97 LMNA (1.00) FPR2LMNAMAPTSMN1; SMN2CYP3A4
Trifluoperazine SCHEMBL29579627 0.97 LMNA (1.00) FPR2LMNAMAPTSMN1; SMN2CYP3A4
Trifluoperazine SCHEMBL466955 0.96 FPR2 (0.96) FPR2LMNAMAPTSMN1; SMN2CYP3A4
Trifluoperazine SCHEMBL28329317 0.93 FPR2 (0.90) FPR2LMNAMAPTSMN1; SMN2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250034193-A1 PHENOTHIAZINE DERIVATIVES AND USES THEREOF CAMP4 THERAPEUTICS CORPORATION 2025-01-30 US disclosed
US-12145963-B2 Phenothiazine derivatives and uses thereof CAMP4 THERAPEUTICS CORPORATION (US) 2024-11-19 US disclosed
US-20230257410-A1 PHENOTHIAZINE DERIVATIVES AND USES THEREOF CAMP4 THERAPEUTICS CORPORATION 2023-08-17 US disclosed
US-20230257410-A1 PHENOTHIAZINE DERIVATIVES AND USES THEREOF CAMP4 THERAPEUTICS CORPORATION 2023-08-17 US disclosed
US-11542290-B2 Phenothiazine derivatives and uses thereof CAMP4 THERAPEUTICS CORPORATION (US) 2023-01-03 US disclosed
US-11542290-B2 Phenothiazine derivatives and uses thereof CAMP4 THERAPEUTICS CORPORATION (US) 2023-01-03 US disclosed
US-20210061837-A1 PHENOTHIAZINE DERIVATIVES AND USES THEREOF CAMP4 THERAPEUTICS CORPORATION 2021-03-04 US disclosed
US-20210061837-A1 PHENOTHIAZINE DERIVATIVES AND USES THEREOF CAMP4 THERAPEUTICS CORPORATION 2021-03-04 US disclosed
WO-2019195789-A1 PHENOTHIAZINE DERIVATIVES AND USES THEREOF CAMP4 THERAPEUTICS CORPORATION (US) 2019-10-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210061837-A1 PHENOTHIAZINE DERIVATIVES AND USES THEREOF RPLP2, RPS2, RPLP1 FPR2 2716/4885LMNA 546/4885MAPT 651/4885
US-20230257410-A1 PHENOTHIAZINE DERIVATIVES AND USES THEREOF RPLP2, RPS2, RPLP1 FPR2 2716/4885LMNA 546/4885MAPT 651/4885
US-12145963-B2 Phenothiazine derivatives and uses thereof RPLP2, RPS2, RPLP1 FPR2 2716/4885LMNA 546/4885MAPT 651/4885
US-20250034193-A1 PHENOTHIAZINE DERIVATIVES AND USES THEREOF RPLP2, RPS2, RPLP1 FPR2 2716/4885LMNA 546/4885MAPT 651/4885
US-11542290-B2 Phenothiazine derivatives and uses thereof RPLP2, RPS2, RPLP1 FPR2 2716/4885LMNA 546/4885MAPT 651/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.