Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trifluoperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 1.00 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 1.00 |
| ▸ | HTR2C known ✓ | P28335 | 3/20 | 1.00 |
| ▸ | DRD3 known ✓ | P35462 | 3/20 | 1.00 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.82 |
| ▸ | FPR2 | P25090 | 11/20 | 1.00 |
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 5/20 | 1.00 |
| ▸ | TP53 | P04637 | 4/20 | 1.00 |
| ▸ | RAD52 | P43351 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | HTR1A | P08908 | 3/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 3/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 3/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoperazine SCHEMBL29603012 | 1.00 | FPR2 (1.00) | FPR2LMNAMAPTSMN1; SMN2CYP3A4 | |
| Trifluoperazine SCHEMBL1897003 | 1.00 | FPR2 (1.00) | FPR2LMNAMAPTSMN1; SMN2CYP3A4 | |
| Trifluoperazine SCHEMBL29430171 | 0.99 | LMNA (1.00) | FPR2LMNAMAPTSMN1; SMN2CYP3A4 | |
| Trifluoperazine SCHEMBL41194 | 0.99 | LMNA (1.00) | FPR2LMNAMAPTSMN1; SMN2CYP3A4 | |
| Trifluoperazine SCHEMBL29579627 | 0.99 | LMNA (1.00) | FPR2LMNAMAPTSMN1; SMN2CYP3A4 | |
| Trifluoperazine SCHEMBL23039392 | 0.99 | LMNA (1.00) | FPR2LMNAMAPTSMN1; SMN2CYP3A4 | |
| Trifluoperazine SCHEMBL341516 | 0.99 | LMNA (1.00) | FPR2LMNAMAPTSMN1; SMN2CYP3A4 | |
| Trifluoperazine SCHEMBL466955 | 0.98 | FPR2 (0.96) | FPR2LMNAMAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL21445272 | 0.98 | FPR2 (1.00) | FPR2LMNAMAPTSMN1; SMN2CYP3A4 | |
| Trifluoperazine SCHEMBL28329317 | 0.95 | FPR2 (0.90) | FPR2LMNAMAPTSMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 21902 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3841097-B1 | 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER | BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) | 2026-05-20 | — | — | EP | claimed |
| US-12624036-B2 | Method of treating post-traumatic stress disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| CN-122028919-A | Compositions and methods for treating cancer by affecting cancer cell membrane receptors and exosomes derived therefrom | 黄奇英 | 2026-05-12 | — | — | CN | claimed |
| US-12624037-B2 | Method of treating agitation, aggressive behavior, and impulse control disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| US-20260098070-A1 | SMAGP FUSION MOLECULES AND METHODS OF USE THEREOF | DEM BIOPHARMA INC (US) | 2026-04-09 | — | — | US | claimed |
| US-20260092932-A1 | METHODS AND COMPOSITIONS FOR THE DETECTION, DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDER | THE JOHNSON CENTER FOR CHILD HEALTH AND DEV (US) | 2026-04-02 | — | — | US | claimed |
| EP-4699659-A2 | CRYSTALLINE FORMS OF EVENAMIDE | Newron Pharmaceuticals S.p.A. (IT) | 2026-02-25 | — | — | EP | claimed |
| EP-4648734-B1 | SUNSCREEN COMPOSITION WITH FUNCTIONALIZED ZEOLITE SPF BOOSTERS | GETTERS SPA (IT) | 2026-02-18 | — | — | EP | claimed |
| US-12550885-B2 | Red blood cell storage solutions, solution additives, and methods for improving the storage of red blood cells | UNIVERSITY OF CINCINNATI (US) | 2026-02-17 | — | — | US | claimed |
| US-4407800-A | TRYPANOCIDES | UNIVERSITY OF VIRGINIA ALUMNI PATENTS FOUNDATION (US) | 1983-10-04 | — | — | US | claimed |
| EP-0082203-A1 | USE OF CALMODULIN BINDING DRUGS IN UTERUS TO PREVENT PREGNANCY | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1983-06-29 | — | — | EP | claimed |
| US-4377577-A | Use of psychoactive drugs in uterus to prevent pregnancy | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1983-03-22 | — | — | US | claimed |
| WO-1983000086-A1 | USE OF CALMODULIN BINDING DRUGS IN UTERUS TO PREVENT PREGNANCY | UNIV GEORGIA RES FOUND (US) | 1983-01-20 | — | — | WO | claimed |
| US-4369172-A | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose | FOREST LABORATORIES INC. (US) | 1983-01-18 | — | — | US | claimed |
| EP-0053108-A1 | VAGINAL CONTRACEPTIVES COMPRISING PSYCHOACTIVE DRUGS | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 1982-06-09 | — | — | EP | claimed |
| WO-1981003421-A1 | USE OF PSYCHOACTIVE DRUGS AS VAGINAL CONTRACEPTIVES | UNIV GEORGIA (US) | 1981-12-10 | — | — | WO | claimed |
| US-4287307-A | MICROCELLULAR, PLASTICIZING, FOOTWEAR | PLASTICS TECHNOLOGY ASSOCIATES, INC. (US) | 1981-09-01 | — | — | US | claimed |
| US-4197288-A | Neuroleptic radioreceptor assay method and kit | BURROUGHS WELLCOME CO. (US) | 1980-04-08 | — | — | US | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |