SCHEMBL214467

SCHEMBL214467

O=C(O)c1cn[nH]c1C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DDR1 Q08345 1/20 0.42
ASPH Q12797 2/20 0.41
NOTUM Q6P988 1/20 0.38
POLB P06746 1/20 0.37
MAPT P10636 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
KDM4E B2RXH2 3/20 0.36
HPGD P15428 2/20 0.36
P2RX7 Q99572 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
HSD17B10 Q99714 2/20 0.35
GAA P10253 1/20 0.35
AHR P35869 1/20 0.35
ALDH1A1 P00352 2/20 0.34
TSHR P16473 1/20 0.34
XDH P47989 1/20 0.33
KDM8 Q8N371 1/20 0.32
HCAR2 Q8TDS4 1/20 0.32
RXRA P19793 1/20 0.32
RXRB P28702 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL29715665 0.98 DDR1 (0.41) DDR1ASPHNOTUMPOLBMAPT
SCHEMBL18130158 0.85 ASPH (0.35) DDR1ASPHNOTUMPOLBMAPT
SCHEMBL30147962 0.82 DDR1 (0.41) DDR1P2RX7HSD17B10GAAAHR
SCHEMBL17057147 0.82 DDR1 (0.41) DDR1SMN1; SMN2P2RX7HSD17B10GAA
SCHEMBL20304370 0.82 PLK4 (0.42) DDR1P2RX7HSD17B10GAAAHR
SCHEMBL23853474 0.82 DDR1 (0.39) DDR1P2RX7HSD17B10GAAAHR
SCHEMBL29106671 0.78 TSHR (0.57) DDR1POLBMAPTSMN1; SMN2KDM4E
SCHEMBL353369 0.78 DDR1 (0.47) DDR1POLBP2RX7HSD17B10GAA
SCHEMBL29913411 0.75 MEN1 (0.43) DDR1KDM4EHSD17B10GAAALDH1A1
Trifluoroacetic Acid SCHEMBL30591159 0.73 MEN1 (0.55) DDR1MAPTSMN1; SMN2KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122076402-A MOF molecular sieve adsorbent and preparation method and application thereof 2026-05-26 CN claimed
CN-117551280-B Fluorinated metal organic framework material for fluorine-containing electron special gas purification and preparation method thereof 天津工业大学 2024-03-15 CN claimed
CN-117586522-A Zinc metal organic framework material for separating ethane/ethylene mixed gas and preparation method thereof 江西师范大学 2024-02-23 CN claimed
CN-117551280-A Fluorinated metal organic framework material for fluorine-containing electron special gas purification and preparation method thereof 天津工业大学 2024-02-13 CN claimed
US-20220128561-A1 METHODS TO DETERMINE WHETHER A SUBJECT IS SUITABLE OF BEING TREATED WITH AN AGONIST OF SOLUBLE GYANYLYL CYCLASE (SGC) BAYER AKTIENGESELLSCHAFT (DE) 2022-04-28 US claimed
CN-107580495-A The sGC stimulants, the sGC activators that combine individually and with PDE5 inhibitor are used for the purposes for treating the finger ulcer (DU) of adjoint system sclerosis (SSc) 拜耳制药股份公司 2018-01-12 CN claimed
WO-2015095515-A1 SGC ACTIVATORS FOR THE TREATMENT OF GLAUCOMA NOVARTIS AG (CH) 2015-06-25 WO claimed
EP-2401265-A2 SOLUBLE GUANYLATE CYCLASE ACTIVATORS Merck Sharp & Dohme Corp. (US) 2012-01-04 EP claimed
CN-122076402-A MOF molecular sieve adsorbent and preparation method and application thereof 2026-05-26 CN disclosed
CN-116710439-B Substituted pyrazolopiperidine carboxylic acids BAYER AG (DE) 2026-05-26 CN disclosed
CN-116829545-B Substituted pyrazolylpiperidine carboxylic acids 拜耳公司 2026-05-15 CN disclosed
US-12427131-B2 Stimulators and/or activators of soluble guanylate cyclase (sGC) in combination with an inhibitor of neutral endopeptidase (NEP inhibitor) and/or an angiotensin AII antagonist and the use thereof BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2025-09-30 US disclosed
WO-2025072539-A1 AMINO ACID COMPOUNDS WITH NITROGEN LINKERS AND USES THEREOF PLIANT THERAPEUTICS, INC. (US) 2025-04-03 WO disclosed
US-20250059196-A1 TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) 2025-02-20 US disclosed
US-20040235831-A1 Composition for caring for the hair or the eyelashes, containing a pyrazolecarboxamide compound, use thereof for stimulating the growth of the hair and the eyelashes and/or for reducing their loss SOCIETE L'OREAL, S.A. (FR) 2004-11-25 US disclosed
WO-2004073594-A2 USE OF AN INHIBITOR OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE IN ORDER TO STIMULATE PIGMENTATION OF THE SKIN OR SKIN APPENDAGES L'OREAL (FR) 2004-09-02 WO disclosed
WO-2004047776-A1 COMPOSITION FOR HAIR CARE OR EYELASHES CONTAINING A PYRAZOL-CARBOXAMIDE, ITS USE FOR STIMULATING HAIR AND EYELASH GROWTH AND/OR FOR PREVENTING LOSS THEREOF L'OREAL (FR) 2004-06-10 WO disclosed
EP-0151866-B1 HERBICIDAL PYRAZOLE-(THIO)-CARBOXAMIDES ELI LILLY AND COMPANY (US) 1990-07-25 EP disclosed
US-4620865-A Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides ELI LILLY AND COMPANY (US) 1986-11-04 US disclosed
EP-0151866-A2 Herbicidal pyrazole-(thio)-carboxamides ELI LILLY AND COMPANY (US) 1985-08-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250059196-A1 TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF WEE1, CYP51A1, WEE2 DDR1 4869/4885ASPH 1494/4885NOTUM 4/4885
US-12427131-B2 Stimulators and/or activators of soluble guanylate cyclase (sGC) in combination with an inhibitor of neutral endopeptidase (NEP inhibitor) and/or an angiotensin AII antagonist and the use thereof MME, ECE1, REN DDR1 1272/4885ASPH 909/4885NOTUM 1566/4885
US-20040235831-A1 Composition for caring for the hair or the eyelashes, containing a pyrazolecarboxamide compound, use thereof for stimulating the growth of the hair and the eyelashes and/or for reducing their loss BCOR, HCRTR1, RCOR1 DDR1 1841/4885ASPH 2811/4885NOTUM 3109/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.