Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144925 | 0.80 | CPB2 (0.41) | BACE1CPB2APP | |
| SCHEMBL2144732 | 0.78 | BACE1 (0.40) | BACE1CPB2 | |
| Tert-Butyl Formate SCHEMBL28793257 | 0.74 | CPB2 (0.34) | BACE1CPB2 | |
| SCHEMBL14881459 | 0.72 | CXCR4 (0.45) | BACE1APP | |
| SCHEMBL13040616 | 0.68 | NOS2 (0.58) | BACE1CPB2APP | |
| SCHEMBL10130655 | 0.65 | NOS2 (0.53) | BACE1CPB2APP | |
| SCHEMBL23153083 | 0.64 | MCHR1 (0.44) | BACE1CPB2APP | |
| SCHEMBL15173735 | 0.64 | GRIN2D (0.49) | — | |
| SCHEMBL27841743 | 0.63 | NOS1 (0.34) | BACE1 | |
| SCHEMBL20920353 | 0.63 | ATM (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | Signal Pharmaceuticals, LLC (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010027500-A1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2010-03-11 | — | — | WO | disclosed |