Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.69 |
| ▸ | PDE1A | P54750 | 1/20 | 0.69 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.69 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | TSHR | P16473 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.54 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14102574 | 0.80 | LMNA (0.67) | PDE5APDE1APDE1BPDE1CMAPT | |
| SCHEMBL21450201 | 0.79 | MAPT (0.73) | PDE5APDE1APDE1BPDE1CMAPT | |
| SCHEMBL21450360 | 0.79 | RAB9A (0.83) | MAPTMEN1KMT2ALMNATSHR | |
| SCHEMBL21450181 | 0.79 | RAB9A (0.78) | MAPTMEN1KMT2ALMNATSHR | |
| SCHEMBL2683107 | 0.78 | NPC1 (0.76) | PDE5APDE1APDE1BPDE1CMAPT | |
| SCHEMBL16434276 | 0.77 | MAPT (0.63) | PDE5APDE1APDE1BPDE1CMAPT | |
| SCHEMBL21450180 | 0.75 | MAPT (0.68) | PDE5APDE1APDE1BPDE1CMAPT | |
| SCHEMBL21436991 | 0.74 | NPSR1 (0.77) | MAPTMEN1KMT2ALMNATSHR | |
| SCHEMBL21437545 | 0.74 | RAB9A (0.65) | MAPTMEN1KMT2ALMNATSHR | |
| SCHEMBL11595205 | 0.74 | CGAS (0.48) | KMT2ALMNARAB9ANPC1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193540-A1 | HETEROARYL DERIVATIVES OF FORMULA (I) AS ATF4 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-10-10 | — | — | WO | disclosed |