Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21433991 | 0.85 | SCN9A (0.46) | FFAR4CHRM2SCN9ACHRM4CHRM1 | |
| SCHEMBL21434015 | 0.83 | ABL1 (0.42) | FFAR4CHRM2CHRM4FAAHNTRK1 | |
| SCHEMBL21452938 | 0.80 | MAPK1 (0.39) | FFAR4CHRM2FAAHCHRM1NTRK1 | |
| SCHEMBL21434003 | 0.79 | FAAH (0.41) | FAAHALOX5APFEN1TRPA1TRPV4 | |
| SCHEMBL21434034 | 0.78 | EPHX2 (0.44) | FFAR4CHRM2CHRM4CHRM1NTRK1 | |
| SCHEMBL21452940 | 0.76 | ABL1 (0.42) | FAAHABL1 | |
| SCHEMBL21433960 | 0.76 | EPHX2 (0.46) | CHRM4EPHX2TRPA1TRPV4 | |
| SCHEMBL21433990 | 0.76 | EPHX2 (0.44) | FFAR4CHRM2CHRM4CHRM1NTRK1 | |
| SCHEMBL21433926 | 0.76 | HTR2B (0.41) | FFAR4CHRM2SCN9AFAAHNTRK1 | |
| SCHEMBL21452690 | 0.75 | CHEK1 (0.44) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193516-A2 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-10 | — | — | WO | disclosed |