Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21434015 | 0.90 | ABL1 (0.42) | GRM2FAAHNTRK1TRPA1TRPV4 | |
| SCHEMBL21452872 | 0.89 | HRH4 (0.39) | SYKGRM2HRH4FAAHNTRK1 | |
| SCHEMBL21453061 | 0.89 | HRH4 (0.39) | SYKGRM2HRH4FAAHNTRK1 | |
| SCHEMBL21434003 | 0.87 | FAAH (0.41) | MAPK1HSD17B10SYKGRM2HRH4 | |
| SCHEMBL21433991 | 0.85 | SCN9A (0.46) | NTRK1FFAR4CHRM2KDM4ECHRM1 | |
| SCHEMBL21433960 | 0.84 | EPHX2 (0.46) | SYKTRPA1TRPV4 | |
| SCHEMBL21433990 | 0.84 | EPHX2 (0.44) | NTRK1TRPA1TRPV4FFAR4CHRM2 | |
| SCHEMBL21433933 | 0.84 | SMPD3 (0.42) | HRH4TRPA1 | |
| SCHEMBL21433926 | 0.83 | HTR2B (0.41) | SYKGRM2FAAHNTRK1FFAR4 | |
| SCHEMBL21453056 | 0.83 | PDE2A (0.38) | SYKGRM2HRH4FAAHTRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193516-A2 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-10 | — | — | WO | disclosed |