Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 2/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21434015 | 0.90 | ABL1 (0.42) | ABL1PDE2AFAAHCDK1CDK2 | |
| SCHEMBL21453056 | 0.89 | PDE2A (0.38) | ABL1PDE2AFAAHHRH4 | |
| SCHEMBL21452872 | 0.88 | HRH4 (0.39) | PDE2AFAAHHRH4 | |
| SCHEMBL21453061 | 0.88 | HRH4 (0.39) | PDE2AFAAHHRH4 | |
| SCHEMBL21434003 | 0.85 | FAAH (0.41) | FAAHHRH4 | |
| SCHEMBL21434096 | 0.84 | SYK (0.45) | HRH4CDK1CDK2 | |
| SCHEMBL21452938 | 0.82 | MAPK1 (0.39) | FAAHHRH4 | |
| SCHEMBL21433998 | 0.81 | DKK1 (0.42) | ABL1 | |
| SCHEMBL21433991 | 0.81 | SCN9A (0.46) | ABL1 | |
| SCHEMBL21433941 | 0.80 | ABL1 (0.38) | ABL1PDE2AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193516-A2 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-10 | — | — | WO | disclosed |