Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21453061 | 0.89 | HRH4 (0.39) | PDE2ATRPA1FAAHHRH4GRM2 | |
| SCHEMBL21452940 | 0.89 | ABL1 (0.42) | PDE2AFAAHHRH4ABL1 | |
| SCHEMBL21452872 | 0.89 | HRH4 (0.39) | PDE2ATRPA1FAAHHRH4GRM2 | |
| SCHEMBL21434003 | 0.86 | FAAH (0.41) | TRPA1FAAHHRH4GRM2SYK | |
| SCHEMBL21453057 | 0.84 | RPS6KB1 (0.42) | PDE2ATRPA1HRH4GRM2 | |
| SCHEMBL21434015 | 0.84 | ABL1 (0.42) | PDE2ATRPA1FAAHGRM2ABL1 | |
| SCHEMBL21452770 | 0.84 | FAAH (0.43) | TRPA1FAAHLRRK2MAP3K12 | |
| SCHEMBL21453059 | 0.84 | NSD2 (0.39) | PDE2ATRPA1FAAHNSD2LRRK2 | |
| SCHEMBL21453058 | 0.84 | NSD2 (0.39) | PDE2ATRPA1FAAHNSD2LRRK2 | |
| SCHEMBL21452938 | 0.83 | MAPK1 (0.39) | TRPA1FAAHHRH4GRM2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193516-A2 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-10 | — | — | WO | disclosed |