Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | GALR2 | O43603 | 1/20 | 0.36 |
| ▸ | GALR1 | P47211 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21453061 | 1.00 | HRH4 (0.39) | HRH4SYKHRH3GRM2NSD2 | |
| SCHEMBL21453056 | 0.89 | PDE2A (0.38) | HRH4SYKGRM2NSD2FAAH | |
| SCHEMBL21452938 | 0.89 | MAPK1 (0.39) | HRH4SYKHRH3GRM2FAAH | |
| SCHEMBL21452940 | 0.88 | ABL1 (0.42) | HRH4FAAHPDE2A | |
| SCHEMBL21434003 | 0.85 | FAAH (0.41) | HRH4SYKGRM2FAAHKDM4E | |
| SCHEMBL21453065 | 0.85 | HRH4 (0.39) | HRH4GRM2KDM4EHTTLRRK2 | |
| SCHEMBL21434096 | 0.84 | SYK (0.45) | HRH4SYK | |
| SCHEMBL21434015 | 0.83 | ABL1 (0.42) | GRM2FAAHCHRM2PDE2ANTRK1 | |
| SCHEMBL21433998 | 0.81 | DKK1 (0.42) | CHRM2CHRM5CHRM1CHRM3NTRK1 | |
| SCHEMBL21433991 | 0.79 | SCN9A (0.46) | CHRM2CHRM1PDK2KDM4ENTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193516-A2 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-10 | — | — | WO | disclosed |