Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 5/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 3/20 | 0.37 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21453059 | 1.00 | NSD2 (0.39) | NSD2BCL2BCL2L1ALOX5APFEN1 | |
| SCHEMBL21453056 | 0.84 | PDE2A (0.38) | NSD2ALOX5APFEN1TRPA1FAAH | |
| SCHEMBL21452770 | 0.84 | FAAH (0.43) | TRPA1FAAHMAP3K12LRRK2 | |
| SCHEMBL21453053 | 0.84 | FAAH (0.43) | TRPA1FAAHMAP3K12LRRK2 | |
| SCHEMBL21452666 | 0.79 | SMPD3 (0.41) | NSD2TRPA1PDE2AABL1SMPD3 | |
| SCHEMBL21452689 | 0.79 | SMPD3 (0.41) | NSD2TRPA1PDE2AABL1SMPD3 | |
| SCHEMBL21434182 | 0.79 | SMPD3 (0.41) | NSD2TRPA1PDE2AABL1SMPD3 | |
| SCHEMBL21434038 | 0.77 | EPHX2 (0.46) | ALOX5APFEN1SMPD3 | |
| SCHEMBL21452771 | 0.73 | KMO (0.50) | LRRK2 | |
| SCHEMBL21434147 | 0.70 | NPC1 (0.53) | ALOX5APFEN1TRPA1FAAHCACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019193516-A2 | SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-10 | — | — | WO | disclosed |