Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.34 |
| ▸ | JAK1 | P23458 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21435100 | 0.86 | — | — | |
| SCHEMBL21449369 | 0.80 | HPGDS (0.48) | HPGDSKDM4EJAK3DDB1CRBN | |
| SCHEMBL21449414 | 0.77 | HPGDS (0.48) | HPGDSKDM4EJAK3DDB1CRBN | |
| SCHEMBL21453678 | 0.76 | — | — | |
| SCHEMBL21435034 | 0.76 | MAP4K1 (0.32) | KDM4E | |
| SCHEMBL21434991 | 0.74 | — | — | |
| SCHEMBL21435020 | 0.69 | CACNA1G (0.36) | HPGDS | |
| SCHEMBL29129054 | 0.68 | KDM4E (0.42) | HPGDSKDM4EJAK3DDB1CRBN | |
| SCHEMBL1299764 | 0.65 | KDM4E (0.44) | HPGDSKDM4EJAK3GPR119JAK1 | |
| SCHEMBL25296230 | 0.64 | GPR119 (0.43) | HPGDSKDM4EGPR119USP30NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019195846-A1 | IMIDAZOPIPERAZINONE INHIBITORS OF TRANSCRIPTION ACTIVATING PROTEINS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-10-10 | — | — | WO | disclosed |