SCHEMBL21453631

SCHEMBL21453631

c1ccc2c(c1)oc1ccc(-c3ccc4c(c3)c3cccc5c6cccc7sc8cccc(c9ccccc9n4c53)c8c76)cc12

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLA2G2A P14555 3/20 0.35
PLA2G4A P47712 3/20 0.35
PLA2G10 O15496 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
HPGD P15428 1/20 0.35
RAB9A P51151 1/20 0.35
KMT2A Q03164 1/20 0.35
LMNA P02545 1/20 0.33
AHR P35869 1/20 0.32
CHEK2 O96017 1/20 0.31
CASP3 P42574 1/20 0.31
SENP7 Q9BQF6 1/20 0.31
SENP6 Q9GZR1 1/20 0.31
HSP90AA1 P07900 1/20 0.31
HSP90AB1 P08238 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21453607 0.95 PLA2G2A (0.34) PLA2G2APLA2G4APLA2G10SMN1; SMN2KDM4E
SCHEMBL21453633 0.94 AHR (0.34) PLA2G2APLA2G4APLA2G10SMN1; SMN2KDM4E
SCHEMBL21453507 0.93 PLA2G2A (0.33) PLA2G2APLA2G4APLA2G10SMN1; SMN2KDM4E
SCHEMBL21453608 0.90 AHR (0.33) PLA2G2APLA2G4APLA2G10SMN1; SMN2KDM4E
SCHEMBL23288296 0.89 AHR (0.33) PLA2G2APLA2G4APLA2G10SMN1; SMN2KDM4E
SCHEMBL21453505 0.89 AHR (0.32) PLA2G2APLA2G4APLA2G10KDM4EMEN1
SCHEMBL21710643 0.89 MAPT (0.42) PLA2G2APLA2G4APLA2G10SMN1; SMN2KDM4E
SCHEMBL21453755 0.88 MAPT (0.41) PLA2G2APLA2G4APLA2G10SMN1; SMN2KDM4E
SCHEMBL21453637 0.87 ALOX5 (0.46)
SCHEMBL21454251 0.85 ALDH1A1 (0.33) SMN1; SMN2KDM4EMEN1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11038121-B2 9 membered ring carbazole compounds Beijing Summer Sprout Technology Co., Ltd. (CN) 2021-06-15 US disclosed
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD (CN) 2019-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11038121-B2 9 membered ring carbazole compounds SLC25A21, OCIAD2, OXA1L PLA2G2A 1788/4885PLA2G4A 2798/4885PLA2G10 3514/4885
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS SLC25A21, OCIAD2, OXA1L PLA2G2A 1788/4885PLA2G4A 2798/4885PLA2G10 3514/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.