SCHEMBL21453754

SCHEMBL21453754

c1ccc2c(c1)oc1cc(-c3ccc4c(c3)c3cccc5c6ccccc6c6ccccc6c6ccccc6n4c53)ccc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 2/20 0.41
MEN1 O00255 5/20 0.40
KMT2A Q03164 5/20 0.40
MAPT P10636 4/20 0.40
ALDH1A1 P00352 4/20 0.40
KDM4E B2RXH2 3/20 0.40
HPGD P15428 3/20 0.40
HCRTR1 O43613 1/20 0.38
PLA2G2A P14555 4/20 0.37
PLA2G4A P47712 4/20 0.37
PLA2G10 O15496 1/20 0.37
NPC1 O15118 3/20 0.37
RAB9A P51151 3/20 0.37
MMP12 P39900 1/20 0.37
MMP13 P45452 1/20 0.37
ATM Q13315 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.34
HTT P42858 2/20 0.34
MAOA P21397 1/20 0.34
POLB P06746 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24130687 0.93 AHR (0.40) AHRMEN1KMT2AMAPTALDH1A1
SCHEMBL21453755 0.93 MAPT (0.41) AHRMEN1KMT2AMAPTALDH1A1
SCHEMBL21710643 0.92 MAPT (0.42) AHRMEN1KMT2AMAPTALDH1A1
SCHEMBL16850756 0.91 MMP12 (0.34) AHRMEN1KMT2AMAPTALDH1A1
SCHEMBL17705017 0.90 AHR (0.44) AHRMEN1KMT2AMAPTALDH1A1
SCHEMBL26286860 0.89 PLA2G2A (0.35) AHRMEN1KMT2AMAPTALDH1A1
SCHEMBL26286319 0.89 PLA2G2A (0.35) AHRMEN1KMT2AMAPTALDH1A1
SCHEMBL18120476 0.89 AHR (0.36) AHRMEN1KMT2AMAPTALDH1A1
SCHEMBL16850744 0.89 MMP12 (0.33) AHRMEN1KMT2AMAPTALDH1A1
SCHEMBL17612054 0.88 TSPO (0.38) AHRMEN1KMT2AMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11038121-B2 9 membered ring carbazole compounds Beijing Summer Sprout Technology Co., Ltd. (CN) 2021-06-15 US disclosed
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD (CN) 2019-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11038121-B2 9 membered ring carbazole compounds SLC25A21, OCIAD2, OXA1L AHR 416/4885MEN1 4538/4885KMT2A 4192/4885
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS SLC25A21, OCIAD2, OXA1L AHR 416/4885MEN1 4538/4885KMT2A 4192/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.