SCHEMBL21454083

SCHEMBL21454083

c1ccc(-c2ccc(-c3ccc4c(c3)c3ccc5sc6cccc7c8ccccc8c8ccccc8n4c3c5c67)cc2)cc1

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TSPO P30536 3/20 0.36
DNM1 Q05193 1/20 0.31
LIMK1 P53667 1/20 0.31
F9 P00740 2/20 0.31
PSEN1 P49768 1/20 0.31
PSEN2 P49810 1/20 0.31
APH1B Q8WW43 1/20 0.31
NCSTN Q92542 1/20 0.31
APH1A Q96BI3 1/20 0.31
PSENEN Q9NZ42 1/20 0.31
PIM3 Q86V86 1/20 0.30
RXRA P19793 1/20 0.30
RXRB P28702 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21453839 0.95 TSPO (0.31) TSPO
SCHEMBL21453833 0.95 TSPO (0.30) TSPO
SCHEMBL21454137 0.93 KDM4E (0.35) TSPO
SCHEMBL21453514 0.93 TSPO (0.36) TSPO
SCHEMBL21453665 0.93 GPR3 (0.34)
SCHEMBL21454229 0.92 TSPO (0.38) TSPODNM1LIMK1PSEN1PSEN2
SCHEMBL21453666 0.92 ALDH1A1 (0.35)
SCHEMBL21454263 0.91 KDM4E (0.40)
SCHEMBL21453775 0.90 TSPO (0.34) TSPODNM1
SCHEMBL21453794 0.90 TSPO (0.32) TSPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11038121-B2 9 membered ring carbazole compounds Beijing Summer Sprout Technology Co., Ltd. (CN) 2021-06-15 US disclosed
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD (CN) 2019-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11038121-B2 9 membered ring carbazole compounds SLC25A21, OCIAD2, OXA1L TSPO 136/4885DNM1 1709/4885LIMK1 3168/4885
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS SLC25A21, OCIAD2, OXA1L TSPO 136/4885DNM1 1709/4885LIMK1 3168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.