SCHEMBL21454090

SCHEMBL21454090

c1ccc(-c2nc(-c3ccccc3)nc(-c3ccc4c(c3)c3ccc5sc6cccc7c8ccccc8c8ccccc8n4c3c5c67)n2)cc1

nearest known ligand 0.31

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
NPY5R Q15761 1/20 0.31
KDM4E B2RXH2 2/20 0.31
HSD17B10 Q99714 2/20 0.31
TSHR P16473 1/20 0.31
ADORA2A P29274 1/20 0.30
ADORA1 P30542 1/20 0.30
NPC1 O15118 1/20 0.30
LMNA P02545 1/20 0.30
TP53 P04637 1/20 0.30
HPGD P15428 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21454087 0.99 NPY5R (0.31) NPY5RKDM4EHSD17B10TSHRADORA2A
SCHEMBL21453797 0.98 NPY5R (0.30) NPY5RKDM4EHSD17B10TSHR
SCHEMBL21454088 0.97 TSPO (0.31) NPY5R
SCHEMBL21453790 0.93 KDM4E (0.33) NPY5RKDM4EHSD17B10TSHRADORA2A
SCHEMBL21453829 0.93
SCHEMBL21454089 0.93 MEN1 (0.37) NPY5RKDM4EADORA2AADORA1LMNA
SCHEMBL21453788 0.92 KDM4E (0.33) NPY5RKDM4EHSD17B10TSHRADORA2A
SCHEMBL26246285 0.92 HSD17B1 (0.32) KDM4EHSD17B10TP53SMN1; SMN2
SCHEMBL21453799 0.92 MEN1 (0.36) KDM4EADORA2AADORA1LMNAHPGD
SCHEMBL21453484 0.91 ADORA2A (0.32) NPY5RKDM4EHSD17B10TSHRADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11038121-B2 9 membered ring carbazole compounds Beijing Summer Sprout Technology Co., Ltd. (CN) 2021-06-15 US disclosed
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD (CN) 2019-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11038121-B2 9 membered ring carbazole compounds SLC25A21, OCIAD2, OXA1L NPY5R 3583/4885KDM4E 3723/4885HSD17B10 1511/4885
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS SLC25A21, OCIAD2, OXA1L NPY5R 3583/4885KDM4E 3723/4885HSD17B10 1511/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.