SCHEMBL21454230

SCHEMBL21454230

c1ccc(-c2ccc3c(c2)c2cc(-c4ccccc4)cc4c5cccc6sc7cccc(c8ccccc8n3c42)c7c65)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSPO P30536 4/20 0.38
DNM1 Q05193 1/20 0.33
PIK3CA P42336 1/20 0.32
PI4KA P42356 1/20 0.32
PI4KB Q9UBF8 1/20 0.32
NPY5R Q15761 1/20 0.31
KDM4E B2RXH2 2/20 0.31
TSHR P16473 1/20 0.31
HSD17B10 Q99714 1/20 0.31
LIMK1 P53667 1/20 0.30
MEN1 O00255 1/20 0.30
ALDH1A1 P00352 1/20 0.30
POLB P06746 1/20 0.30
MAPT P10636 1/20 0.30
HPGD P15428 1/20 0.30
HTT P42858 1/20 0.30
KMT2A Q03164 1/20 0.30
PSEN1 P49768 1/20 0.30
PSEN2 P49810 1/20 0.30
APH1B Q8WW43 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21454229 0.96 TSPO (0.38) TSPODNM1PIK3CAPI4KAPI4KB
SCHEMBL21454231 0.96 KDM4E (0.33) TSPOPIK3CAPI4KAPI4KBKDM4E
SCHEMBL21453776 0.95 TSPO (0.34) TSPOPIK3CAPI4KAPI4KB
SCHEMBL21453616 0.92 KDM4E (0.31) TSPOKDM4ETSHRHSD17B10MEN1
SCHEMBL21454246 0.91 TSPO (0.33) TSPOPIK3CAPI4KAPI4KB
SCHEMBL21453775 0.91 TSPO (0.34) TSPODNM1PIK3CAPI4KAPI4KB
SCHEMBL21453823 0.89 KDM4E (0.39) TSPODNM1KDM4EHSD17B10
SCHEMBL21454083 0.89 TSPO (0.36) TSPODNM1LIMK1PSEN1PSEN2
SCHEMBL21453794 0.88 TSPO (0.32) TSPOKDM4EMEN1ALDH1A1POLB
SCHEMBL26286588 0.88 KDM4E (0.32) TSPOKDM4EMEN1ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11038121-B2 9 membered ring carbazole compounds Beijing Summer Sprout Technology Co., Ltd. (CN) 2021-06-15 US disclosed
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS BEIJING SUMMER SPROUT TECHNOLOGY CO., LTD (CN) 2019-10-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11038121-B2 9 membered ring carbazole compounds SLC25A21, OCIAD2, OXA1L TSPO 136/4885DNM1 1709/4885PIK3CA 3855/4885
US-20190312214-A1 9 MEMBERED RING CARBAZOLE COMPOUNDS SLC25A21, OCIAD2, OXA1L TSPO 136/4885DNM1 1709/4885PIK3CA 3855/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.