Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ACP1 | P24666 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984755 | 0.86 | LMNA (0.56) | LMNAMAP3K14ADRA1DGAAPKM | |
| SCHEMBL9714248 | 0.85 | LMNA (0.55) | LMNAMAP3K14ADRA1DGAAACP1 | |
| SCHEMBL9714543 | 0.85 | LMNA (0.55) | LMNAMAP3K14ADRA1DGAAACP1 | |
| SCHEMBL18050881 | 0.84 | PKM (0.44) | LMNAGAAPKMTSHRACP1 | |
| SCHEMBL9714613 | 0.83 | CYP11B1 (0.50) | LMNAGAAPKMTSHRMEN1 | |
| SCHEMBL18050884 | 0.83 | ATM (0.44) | LMNAGAAPKMTSHRALDH1A1 | |
| SCHEMBL7985416 | 0.80 | LMNA (0.50) | LMNAMAP3K14ADRA1DACP1MEN1 | |
| SCHEMBL18050891 | 0.80 | TSHR (0.47) | LMNAGAAPKMTSHRACP1 | |
| SCHEMBL18050890 | 0.78 | SCD (0.56) | LMNAADRA1DGAAPKMTSHR | |
| SCHEMBL18050896 | 0.77 | PKM (0.46) | LMNAADRA1DGAAPKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | claimed |
| EP-0248414-B1 | ARALKYL IMIDAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-09-23 | — | — | EP | disclosed |
| US-4851424-A | 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds which are useful in the treatment of epilepsy | CIBA-GEIGY CORPORATION (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0248414-A2 | Aralkyl imidazole derivatives | CIBA-GEIGY AG (CH) | 1987-12-09 | — | — | EP | disclosed |