Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7984755 | 0.85 | LMNA (0.56) | LMNAMAP3K14ADRA1DGAAACP1 | |
| SCHEMBL214548 | 0.85 | LMNA (0.56) | LMNAMAP3K14ADRA1DGAAACP1 | |
| SCHEMBL10570732 | 0.83 | ALDH1A1 (0.52) | LMNAMAP3K14GAAACP1MEN1 | |
| SCHEMBL9714248 | 0.81 | LMNA (0.55) | LMNAMAP3K14ADRA1DGAAACP1 | |
| SCHEMBL7034716 | 0.78 | MEN1 (0.51) | LMNAMAP3K14GAAACP1MEN1 | |
| SCHEMBL7985416 | 0.77 | LMNA (0.50) | LMNAMAP3K14ADRA1DACP1MEN1 | |
| SCHEMBL9714155 | 0.75 | CA5A (0.47) | GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL10568713 | 0.74 | ALDH1A1 (0.51) | LMNAGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL9714613 | 0.74 | CYP11B1 (0.50) | LMNAGAAMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL7989254 | 0.73 | CYP11B1 (0.49) | LMNAMEN1KMT2AALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248414-B1 | ARALKYL IMIDAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1992-09-23 | — | — | EP | disclosed |
| US-4851424-A | 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds which are useful in the treatment of epilepsy | CIBA-GEIGY CORPORATION (US) | 1989-07-25 | — | — | US | disclosed |
| EP-0248414-A2 | Aralkyl imidazole derivatives | CIBA-GEIGY AG (CH) | 1987-12-09 | — | — | EP | disclosed |